DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and RGD2

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_428268.1	Gene:	RGD2 / 850497	SGDID:	S000001847	Length:	714	Species:	Saccharomyces cerevisiae

Alignment Length:	298	Identity:	69/298 - (23%)
Similarity:	114/298 - (38%)	Gaps:	84/298 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDDQLLQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELI 69
            |:|  |.:|.|..::         |:..|.:.|:...||...|...|..:.:.|      :|  |
Yeast    10 SED--LVSGLDVLFD---------RLYHGCEQCDLFIQLFASRMQFEVSHGRQL------FG--I 55

  Fly    70 EKG-----------PEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTL 123
            |.|           .|..|...|.:|:|.|..:....|:.|..|:.:.|......|..|  |...
Yeast    56 EAGMDNLKAVQEDEDEGVTVSRALRGILQEMSQEGTHHLTIASNIESLVLQPFSKWCIE--HRER 118

  Fly   124 MQIKERKDLEDL--FKKAQKPWAKLLAKVEKAKADYHSACKT----ERSATNQERNANADSSLSP 182
            :|..|:..|.::  |:|::    |.:.|:||   :|.:.|:.    :|:..|::..|||..||
Yeast   119 IQYSEKTLLTNVNNFRKSK----KYVGKLEK---EYFNKCRQLEEFKRTHFNEDELANAMKSL-- 174

  Fly   183 DQVKKMHDRVQKTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILF 247
                              |.:.|||:.:|....:.  :...:..:....:|.::| ||
Yeast   175 ------------------KIQNKYEEDVAREKDHR--FFNRIAGIDFDYKTMKET-LQ------- 211

  Fly   248 NVHSCLDLTKV----QSLPQIYEEFSHTINNADQQKDL 281
                 |.|||:    ..||.|....|:|.|..:..|.|
Yeast   212 -----LLLTKLPKTDYKLPLISYSLSNTNNGGEITKFL 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	60/275 (22%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777
RGD2	NP_428268.1	FCH	6..96	CDD:214492	24/104 (23%)
		DEP_fRgd2	205..289	CDD:239883	16/53 (30%)
		RhoGAP_fRGD2	473..708	CDD:239864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010