DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synd and MGC147475

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001072681.1	Gene:	MGC147475 / 780138	XenbaseID:	XB-GENE-5872932	Length:	404	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	170/483 - (35%)
Similarity:	257/483 - (53%)	Gaps:	100/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTT 78
            :||||.|.||..|.||:||||:||:::....|:||.||:.||..:..|::||..|::..|.||:.
Frog    15 TDSFWMPNNYGSTVKRMEDGYRLCDEIVACFQDRAKIERQYALQMEEWTRKWKPLVDSSPMYGSL 79

  Fly    79 EAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLEDLFKKAQKP 142
            ..||:..::.:||:|::|.:|:..|..:...:|:||||:.||..:. ..||..::|:.|.|||||
Frog    80 LRAWQAFMSATERLSELHTQIQKTLVAEDAEKIRTWQKDTYHRKIFGGFKESCEIENGFHKAQKP 144

  Fly   143 WAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCREKYE 207
            |||.|.||||:||.||.|||.|...:.:|.::..:..|:.:::||:.:..:|.....:|.:::||
Frog   145 WAKKLKKVEKSKAIYHKACKKEHLVSVRENSSKINPELTQEKLKKLAEDHEKCTQDKEKVKQRYE 209

  Fly   208 QAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEEFSHTI 272
            :::.|:.|||..|:|:|.:||::.|..|:.::.|.|::|.::|..||:|..:|..::|.:.:..|
Frog   210 KSLQELNKYNPKYMEEMETVFDQSQQQEQKKILFLKQVLESMHKHLDITTNESAKKVYSDLNDAI 274

  Fly   273 NNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEF-RDIAKGNKSKEALPAAPITLINQRPVAEDV 336
            ...:.|:|||||.|.||..|.||||...|:|.:. :.|.|..|.||
Frog   275 VGVNDQEDLKWWKNKHGPGMIMNWPQLKEWTPDTEQQIVKKKKVKE------------------- 320

  Fly   337 HQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATAAATAASAAS 401
                  |:.:|                      ..|||.:|                       |
Frog   321 ------TDKVK----------------------LYSVTPTE-----------------------S 334

  Fly   402 NRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQGDVFEK 466
            ::|.:..|                           .|||.|:|:|||.|.|||||:||.||...|
Frog   335 SQNKAPIN---------------------------VPGVRVRAVYDYSGQESDELSFKSGDELTK 372

  Fly   467 LEDEDEQGWCKGRMN-GRVGLYPANYVE 493
            :|||||||||||..: |:||||||||||
Frog   373 IEDEDEQGWCKGVTDKGQVGLYPANYVE 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	96/255 (38%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	36/52 (69%)
MGC147475	NP_001072681.1	F-BAR_PACSIN	18..275	CDD:153339	96/256 (38%)
MGC147475	NP_001072681.1	SH3	345..400	CDD:388381	38/54 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8788
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030