DRSC/TRiP Functional Genomics Resources

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Protein Alignment Synd and ITSN1

DIOPT Version :9

Sequence 1:NP_001262786.1 Gene:Synd / 42467 FlyBaseID:FBgn0053094 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens


Alignment Length:512 Identity:99/512 - (19%)
Similarity:180/512 - (35%) Gaps:149/512 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 ERISDVHMKIKDNLCN-DV-NSQIKTWQKENYHHTLMQIKERKDLEDLFKKAQKPWAKLLAKVEK 152
            :::.:|..:.:..|.. |: |:|:|..::   .|...|::::|.:| ..:..||...:.:.::||
Human   584 DQLDEVEKETRSKLQEIDIFNNQLKELRE---IHNKQQLQKQKSME-AERLKQKEQERKIIELEK 644

  Fly   153 AKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQ-------KTKDQVQKCREKYEQAI 210
            .|.:.....: ||.....|.....|....|   :|:|:..:       |.||..:|.:::.:..:
Human   645 QKEEAQRRAQ-ERDKQWLEHVQQEDEHQRP---RKLHEEEKLKREESVKKKDGEEKGKQEAQDKL 705

  Fly   211 AEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIY--EEFSH--- 270
            ..:  ::........:|.....|.||..|..         |..:..||.....:|  |..||   
Human   706 GRL--FHQHQEPAKPAVQAPWSTAEKGPLTI---------SAQENVKVVYYRALYPFESRSHDEI 759

  Fly   271 TINNAD------------QQKDLKWWSNNHGINMAMNW-PSFVEYTEEFRDIAKGNKSKEALPAA 322
            ||...|            |..:..|....  :.....| |:  .|.|         |..|....|
Human   760 TIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPA--NYAE---------KIPENEVPA 811

  Fly   323 PITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVK----SEIATTQSSVTTSEAKT--- 380
            |:     :||.:......|:. :|::..:.|:..||..|..    ::.::|..:.|..:.:|   
Human   812 PV-----KPVTDSTSAPAPKL-ALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNW 870

  Fly   381 ---------SAAVAGAATATAAATAASAASNRNSSVTNGNGKVDA------NPF----DEEEEWD 426
                     :...||.....:|.|.|:|..:..|.|.....||:.      .|:    |....::
Human   871 DAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFN 935

  Fly   427 ESDNVLV-------------------------------------DNGEPGVPVK----------- 443
            ::|.:.|                                     |:|....|..           
Human   936 KNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKP 1000

  Fly   444 --------ALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYV 492
                    |:|.||.:|..:|||:||||.  |..:.:..|..|.:..:.|::|:|||
Human  1001 VVSGEEFIAMYTYESSEQGDLTFQQGDVI--LVTKKDGDWWTGTVGDKAGVFPSNYV 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SyndNP_001262786.1 F-BAR_PACSIN 17..272 CDD:153339 38/195 (19%)
SH3_PACSIN 441..493 CDD:212777 21/71 (30%)
ITSN1NP_003015.2 EH 14..108 CDD:197477
EH 26..90 CDD:238009
EH 214..309 CDD:197477
EH 225..291 CDD:238009
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348
KLERQ 326..702 26/125 (21%)
GBP_C <331..414 CDD:303769
COG1340 372..686 CDD:224259 22/109 (20%)
coiled coil 383..394 CDD:293879
coiled coil 403..414 CDD:293879
AAA_23 <509..636 CDD:290211 12/55 (22%)
GBP_C <616..686 CDD:303769 15/74 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 11/54 (20%)
SH3_Intersectin1_1 744..803 CDD:212920 13/71 (18%)
INTAP 803..917 CDD:293223 25/119 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 6/31 (19%)
SH3_Intersectin1_2 917..968 CDD:212922 4/50 (8%)
SH3_Intersectin1_3 1006..1057 CDD:212924 20/52 (38%)
SH3_Intersectin1_4 1074..1138 CDD:212926
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127
SH3_Intersectin1_5 1158..1211 CDD:212928
RhoGEF 1242..1422 CDD:279015
PH_ITSN 1448..1579 CDD:270084
PH 1465..1571 CDD:278594
C2_Intersectin 1582..1716 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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