DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and FNBP1L

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001157945.1	Gene:	FNBP1L / 54874	HGNCID:	20851	Length:	605	Species:	Homo sapiens

Alignment Length:	640	Identity:	125/640 - (19%)
Similarity:	219/640 - (34%)	Gaps:	216/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKW---GELIEKGPEYGTTE 79
            |:  .:....|..:.|........:.::||.:||:.|||.||...||:   ....::.|.: |:.
Human     8 WD--QFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRF-TSC 69

  Fly    80 AAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTL-----MQIKERKDLEDLF--- 136
            .|:..:|.|....:.....:.:.:.:.|..::.     .|.|.|     |.::|.:..:...
Human    70 VAFFNILNELNDYAGQREVVAEEMAHRVYGELM-----RYAHDLKTERKMHLQEGRKAQQYLDMC 129

  Fly   137 ------------------KKAQKPWAKL-------LAKVEKAKADY----HSACKTERSATNQER 172
                              :|||:.:.:|       .|.|||||...    |.|.:.:.....|.:
Human   130 WKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQ 194

  Fly   173 NANADSS-----LSPD---QVKKMHDR---------------VQKTKDQVQKCR----------- 203
            |.|.:..     :.|.   |:::|.:|               .:|....:.||.
Human   195 NFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVD 259

  Fly   204 ------------------------EKYEQAI--------AEITKYNSVYIEDMTSVFE---KCQT 233
                                    |.|.|.|        ...:|..|..::..|:|.:   |...
Human   260 ERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLWL 324

  Fly   234 FEK-----------TRL---------QFFKEILFNVHSCLDLTKVQSLPQI-------------- 264
            |.|           |.|         ||....:..||.|::..|. ..|:|
Human   325 FGKKPKPQSPPLTPTSLFTSSTPNGSQFLTFSIEPVHYCMNEIKT-GKPRIPSFRSLKRGWSVKM 388

  Fly   265 ---YEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITL 326
               .|:|||.   ..:|:..|.......:|               |::.|.:..|:||
Human   389 GPALEDFSHL---PPEQRRKKLQQRIDELN---------------RELQKESDQKDAL------- 428

  Fly   327 INQRPVAEDVHQEYPQ---TNSLK-KNTSTLSSVSSRASVKSEIATTQSSVTTSEAKT------- 380
             |:   .:||:::.||   ..||: |...|::::.   .::.||...::.::..|.||
Human   429 -NK---MKDVYEKNPQMGDPGSLQPKLAETMNNID---RLRMEIHKNEAWLSEVEGKTGGRGDRR 486

  Fly   381 -SAAVAGAATATAAATAASAASNRNSSV-----TNGNGKVDANPFDEEEEWDESDNVLVDNGEPG 439
             |:.:....|....:...|...:.|..|     .:|:    .|.||:|   .|.|:.|...|.
Human   487 HSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGH----HNEFDDE---FEDDDPLPAIGH-- 542

  Fly   440 VPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKG-RMNGRVGLYPANYVE 493
              .||:|.::|.....|..|:|:|...:|::...||.:. |.||..|..|.:|::
Human   543 --CKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYID 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	72/399 (18%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	17/52 (33%)
FNBP1L	NP_001157945.1	F-BAR_FNBP1L	5..256	CDD:153359	47/255 (18%)
		Interaction with CDC42	245..535		60/329 (18%)
		HR1_CIP4_FNBP1L	399..479	CDD:212018	20/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..539		16/69 (23%)
		Interaction with DNM1. /evidence=ECO:0000269\|PubMed:16326391	522..605		26/85 (31%)
		Interaction with DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000269\|PubMed:16630611	541..605		18/59 (31%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000269\|PubMed:16418535	541..597		18/59 (31%)
		SH3_FNBP1L	541..597	CDD:213005	18/59 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940