Protein Alignment Synd and pacsin2

DIOPT Version :10

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: XP_031753729.1
• Gene: pacsin2 / 496460
• XenbaseID: XB-GENE-489578
• Length: 479
• Species: Xenopus tropicalis
• Alignment Length: 502
• Identity: 225/502 - (44%)
• Similarity: 316/502 - (62%)
• Gaps: 33/502 - (6%)

  Fly     1 MSHHSDDQL-LQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKK 64
            ||...||.: ::..||||||.||||||.|||:||::||:||...|.|||.|||.||:.|..|:|:
 Frog     1 MSGTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCIHERAKIEKAYAQQLTEWAKR 65

  Fly    65 WGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKE 128
            |.:|:|:||:|||.|.||..::||:|::|::|:::|:.|.|:...:||.||||.:|..:| ..||
 Frog    66 WKQLVERGPQYGTVEKAWHNLMTEAEKVSELHLEVKNALMNEDFEKIKNWQKEAFHKQMMGGFKE 130

  Fly   129 RKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQ 193
            .|:.||.|:||||||||.|.:||.||..||:|||.|:.||::|.|:.||.:::|:|:||:.|:|:
 Frog   131 TKEAEDGFRKAQKPWAKKLKEVEAAKKAYHAACKEEKLATSRETNSKADPAMNPEQLKKLQDKVE 195

  Fly   194 KTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKV 258
            |:|...||.:||||:|:.::......|:|:|..|||:||.||..||:||:|:|..|...|||:.|
 Frog   196 KSKQDSQKTKEKYEKALKDLDGTTPQYMENMEQVFEQCQQFEDKRLRFFREVLLEVEKHLDLSNV 260

  Fly   259 QSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEF-----RDIAKGNKSKEA 318
            .|...||.|..:.|.:||..:||||:.||:|..|:||||.|.:  ||:     |.:::..|.|
 Frog   261 DSYANIYRELEYAIKSADATEDLKWFRNNNGPGMSMNWPQFED--EEWSADLNRTLSRREKKK-- 321

  Fly   319 LPAAPITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAA 383
             |...:||.......|    :.|..|....:.|..|..|:....:.|..|  .|:..:|.|.:..
 Frog   322 -PTDGVTLTGISQAGE----QAPVQNKHSSHLSVQSVPSANNPFEDEEDT--GSINETENKKTKN 379

  Fly   384 VAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDY 448
            | |:...|..|..:...||...:..:.||  |:|||||:..           |...|.|:|||||
 Frog   380 V-GSYDKTYPAEWSDDESNNPFTANDANG--DSNPFDEDAP-----------GATEVRVRALYDY 430

  Fly   449 EGAESDELTFKQGDVFEKLEDEDEQGWCKGRMN-GRVGLYPANYVET 494
            ||.|.|||:||.|:...|:||||||||||||:: |:||||||||||:
 Frog   431 EGQELDELSFKAGEELTKIEDEDEQGWCKGRLDGGQVGLYPANYVES 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	128/255 (50%)
		SH3_PACSIN	441..493	CDD:212777	37/52 (71%)
pacsin2	XP_031753729.1	F-BAR_PACSIN2	18..275	CDD:153363	128/256 (50%)
		SH3_PACSIN1-2	422..477	CDD:212931	39/54 (72%)