DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synd and pacsin2

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_005168648.1	Gene:	pacsin2 / 404601	ZFINID:	ZDB-GENE-040426-2596	Length:	491	Species:	Danio rerio

Alignment Length:	515	Identity:	217/515 - (42%)
Similarity:	299/515 - (58%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DDQLLQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIE 70
            :|.|:...||||||.|||||:.||::||.:|||||...:.|||.|||.|:..|..|:|:|.:.||
Zfish     5 NDSLIDVSSDSFWEVGNYKRSVKRVDDGNRLCNDLMSCLHERARIEKSYSTQLTDWAKRWRQTIE 69

  Fly    71 KGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLED 134
            |||:|||.|.||..::||:|::||:||::|..|..:...:||.|||:.||..:: ..||.|:.||
Zfish    70 KGPQYGTVERAWCALMTEAEKVSDLHMEVKAALMAEDFEKIKNWQKDAYHKQMIGGFKETKEAED 134

  Fly   135 LFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQV 199
            .|:||||||||.|.::|..|..||:|||.|::||::|.::..|:| :|:..||:.::|:|.:.:|
Zfish   135 GFRKAQKPWAKKLKEMETMKKAYHTACKEEKTATSRENSSKLDNS-NPEAQKKLQEKVEKCQQEV 198

  Fly   200 QKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQI 264
            ||.:|:||:::.::.|....|:|:|..|||:.|.||..||.||||:|..|...|||:.......:
Zfish   199 QKTKERYEKSLEDLDKVTPQYMENMEQVFEQWQQFEGKRLSFFKEVLLEVKQHLDLSSNHKYTTV 263

  Fly   265 YEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQ 329
            |.....||..||.|:||||:.:|||..|.||||.|.|::.:........::|.. ||..:||
Zfish   264 YHTLQDTIQGADPQEDLKWFRSNHGPGMTMNWPQFEEWSMDLNRTLSRRETKRR-PAEGVTL--- 324

  Fly   330 RPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSE----------------------IATTQSS 372
                          .::..|....|.|||..:|.|.                      :..|.||
Zfish   325 --------------TAISHNPEQSSRVSSVPAVSSSEAACLNPFDDDDDDEDEDEEPVVTHTHSS 375

  Fly   373 VTTSE---AKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVD 434
            ....|   |:|||||. .|.|.||.|||....:..|.....:...:.|||:||           .
Zfish   376 PVKHEEAVAQTSAAVE-KAPAPAAITAADDDDDEESGNPFSSSSANGNPFEEE-----------P 428

  Fly   435 NGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            :.|..|||:|:|||||.|.|||:||.||...||.:||||||||||: ||.||||||||||
Zfish   429 STEMCVPVRAVYDYEGQEQDELSFKAGDELVKLSEEDEQGWCKGRLSNGTVGLYPANYVE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	116/255 (45%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	38/52 (73%)
pacsin2	XP_005168648.1	F-BAR_PACSIN2	16..272	CDD:153363	117/256 (46%)
pacsin2	XP_005168648.1	SH3_PACSIN	435..488	CDD:212777	38/52 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595357
Domainoid	1	1.000	210	1.000	Domainoid score	I2753
eggNOG	1	0.900	-	-		E1_KOG2856
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21414
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1896
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm25103
orthoMCL	1	0.900	-	-		OOG6_104815
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770