DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synd and Pacsin3

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001009966.2	Gene:	Pacsin3 / 311187	RGDID:	1307327	Length:	424	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	177/492 - (35%)
Similarity:	274/492 - (55%)	Gaps:	88/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AGSD----SFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKG 72
            ||.:    ||||.|||:||.:|:|||::||.||....||||.|||.||:.|..|::||...:|||
  Rat     7 AGGEVLGGSFWEAGNYRRTVQRVEDGHRLCGDLISCFQERARIEKAYAQQLADWARKWRGAVEKG 71

  Fly    73 PEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLEDLF 136
            |:|||.|.||....|.:||:|::|:::::.|....:.:::|||:..:|..:: ..:|.:..||.|
  Rat    72 PQYGTLEKAWHAFFTAAERLSELHLEVREKLHGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGF 136

  Fly   137 KKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQK 201
            :||||||.|.|.:||.:|..||:|.|.|::|..:|.:|.||||:|.:|::|:.:||.:...:.:|
  Rat   137 RKAQKPWLKRLKEVEASKKSYHTARKDEKTAQTRESHAKADSSMSQEQLRKLQERVGRCTKEAEK 201

  Fly   202 CREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYE 266
            .:.:|||.:||:.:|...|:|||...||.||..|:.||.|||::|..:|..|||:......:::.
  Rat   202 MKTQYEQTLAELNRYTPRYMEDMEQAFESCQAAERQRLLFFKDVLLTLHQHLDLSSSDKFHELHR 266

  Fly   267 EFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYT-EEFRDIA---KGNKSKEALPAAPITLI 327
            :....|.:|..::||:||.:.||..||||||.|.|:: :..|.|:   ||.:|.:.:
  Rat   267 DLQRGIEDASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRAISRKEKGGRSPDEV-------- 323

  Fly   328 NQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATA 392
                                    ||:|:         :.|...:....::.:|.
  Rat   324 ------------------------TLTSI---------VPTRDGTAPPPQSPSSP---------- 345

  Fly   393 AATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELT 457
                             |:|        ::|:|  ||.........||.|:|||||.|.|:|||:
  Rat   346 -----------------GSG--------QDEDW--SDEESPRKAGTGVRVRALYDYAGQEADELS 383

  Fly   458 FKQGDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            |:.|:...|:.:|||||||:|:: :||:|||||||||
  Rat   384 FRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	107/255 (42%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	31/52 (60%)
Pacsin3	NP_001009966.2	BAR	16..273	CDD:416402	107/256 (42%)
Pacsin3	NP_001009966.2	SH3_PACSIN3	365..420	CDD:212930	33/54 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353260
Domainoid	1	1.000	225	1.000	Domainoid score	I2447
eggNOG	1	0.900	-	-		E1_KOG2856
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1760
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm44810
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23065
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870