DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and Pstpip1

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001100294.2	Gene:	Pstpip1 / 300732	RGDID:	1307557	Length:	416	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	111/498 - (22%)
Similarity:	193/498 - (38%)	Gaps:	111/498 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DSFW-----EPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPE 74
            |:||     ....|:...:|:.||.|:|.|:::|:::||..|:.|.|.|...::|.|
  Rat     9 DAFWCRDFTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKAG-------- 65

  Fly    75 YGTTE-----AAWKGVLTESERISDVHMKIKDNLCNDVNS--QIKTWQKENYHHTLMQIKERKDL 132
             |.||     .::..:..::|.:...|:::...|..::.|  :.:..|||          :||..
  Rat    66 -GQTEMNSLRTSFDSLKQQTENVGSAHIQLALALREELRSLEEFRERQKE----------QRKKY 119

  Fly   133 EDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKD 197
            |.:..:.||....|..|..::|..|...|:....|  ::......:|....|::|...:.::.|:
  Rat   120 EAVMDRVQKSKLSLYKKTMESKKSYDQKCRDADDA--EQAFERVSASGHQKQIEKSQTKAKQCKE 182

  Fly   198 QVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSL- 261
            ...:....|.|.|.::.|..:.:.::..:..|..|..|..||...:..|: || |..|: :|.:
  Rat   183 SATEADRVYRQNIEQLEKARTEWEQEHRTTCEAFQLQEFDRLTILRNALW-VH-CNQLS-MQCVK 244

  Fly   262 -PQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPIT 325
             .::|||...|:...|.:.|:.               .|::           :||....|.||:.
  Rat   245 DDELYEEVRLTLEGCDVEGDIN---------------GFIQ-----------SKSTGREPPAPVP 283

  Fly   326 LIN--QRPVAEDVHQEYPQTNS--LKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAG 386
            ..|  .|.|.........||:.  :|:.:..|.........::..|:|::...|||.|
  Rat   284 YQNYYDREVTPLTGSPIVQTSCGVIKRFSGLLHGSPKTTPSQAPAASTETLAPTSEQK------- 341

  Fly   387 AATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGA 451
             ....|:....:...|.||:..:                                .:|||||...
  Rat   342 -ELVYASIEVQATQGNLNSAAQD--------------------------------YRALYDYTAQ 373

  Fly   452 ESDELTFKQGDVFEK-LEDEDEQGWCKGRMNGRVGLYPANYVE 493
            .||||....||:... ||.||  ||.....||:.|..|.:|:|
  Rat   374 NSDELDISAGDILAVILEGED--GWWTVERNGQRGFVPGSYLE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	61/268 (23%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	22/52 (42%)
Pstpip1	NP_001100294.2	BAR	16..257	CDD:299863	60/264 (23%)
Pstpip1	NP_001100294.2	SH3_PSTPIP1	363..415	CDD:212758	23/86 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D727724at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920