Protein Alignment Synd and PACSIN1

DIOPT Version :9

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001186512.1
• Gene: PACSIN1 / 29993
• HGNCID: 8570
• Length: 444
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 203/500 - (40%)
• Similarity: 290/500 - (57%)
• Gaps: 65/500 - (13%)

  Fly     1 MSHHSDDQLL--QAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSK 63
            ||...|:..|  :..:|||||.||||||.|||:||::|||||...:||||.|||.|.:.|..|:|
Human     1 MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAK 65

  Fly    64 KWGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIK 127
            :|.:||||||:||:.|.||..::||::::|::|.::|:||.|:...::|.|||:.||..:| ..|
Human    66 RWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFK 130

  Fly   128 ERKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRV 192
            |.|:.||.|:||||||||.:.::|.||..||.|||.|:.|..:|.|:..:.|::|:|.||:.|:|
Human   131 ETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKV 195

  Fly   193 QKTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTK 257
            .|.|..|||.:||||:.:.::.|....|:|:|..|||:||.||:.||.|.||:|.::...|:|.:
Human   196 DKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAE 260

  Fly   258 VQSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAA 322
            ..|...:|.|....|..||.|:||:|:.:..|..|.||||.|.|:..   |:......||..|
Human   261 NSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNP---DLPHTTTKKEKQP-- 320

  Fly   323 PITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGA 387
                                     |....::..::..:|:|          ||:|....:|:..
Human   321 -------------------------KKAEGVALTNATGAVES----------TSQAGDRGSVSSY 350

  Fly   388 ATATAAATAASAASNRN---SSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYE 449
            ......||..|...:.|   .|.|||.    ||||:::.:              ||.|:|||||:
Human   351 DRGQPYATEWSDDESGNPFGGSETNGG----ANPFEDDSK--------------GVRVRALYDYD 397

  Fly   450 GAESDELTFKQGDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            |.|.|||:||.||...||.:|||||||:||: :|::|||||||||
Human   398 GQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	121/255 (47%)
		SH3_PACSIN	441..493	CDD:212777	34/52 (65%)
PACSIN1	NP_001186512.1	F-BAR_PACSIN1	19..276	CDD:153364	121/256 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..194		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..386		22/117 (19%)
		SH3_PACSIN1-2	388..443	CDD:212931	36/54 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159241
Domainoid	1	1.000	222	1.000	Domainoid score	I2594
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1836
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm40674
orthoMCL	1	0.900	-	-		OOG6_104815
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900