DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and PACSIN3

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001171903.1	Gene:	PACSIN3 / 29763	HGNCID:	8572	Length:	424	Species:	Homo sapiens

Alignment Length:	489	Identity:	176/489 - (35%)
Similarity:	268/489 - (54%)	Gaps:	84/489 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEY 75
            :|...||||.|||:||.:|:|||::||.||....||||.|||.||:.|..|::||...:||||:|
Human    10 EALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQY 74

  Fly    76 GTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLEDLFKKA 139
            ||.|.||....|.:||:|.:|:::::.|....:.:::.||:..:|..:: ..:|.:..||.|:||
Human    75 GTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFRKA 139

  Fly   140 QKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCRE 204
            ||||.|.|.:||.:|..||:|.|.|::|..:|.:|.|||::|.:|::|:.:||::...:.:|.:.
Human   140 QKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKA 204

  Fly   205 KYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEEFS 269
            :|||.:||:.:|...|:|||...||.||..|:.||.|||::|..:|..|||:..:...:::.:..
Human   205 QYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLH 269

  Fly   270 HTINNADQQKDLKWWSNNHGINMAMNWPSFVEYT-EEFRDIA---KGNKSKEALPAAPITLINQR 330
            ..|..|..::||:||.:.||..||||||.|.|:: :..|.|:   ||.:|.:.:
Human   270 QGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEV----------- 323

  Fly   331 PVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATAAAT 395
                                 ||:|:                                    ..|
Human   324 ---------------------TLTSI------------------------------------VPT 331

  Fly   396 AASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQ 460
            ....|....|..:.|.|        ::|||  ||.........||.|:|||||.|.|:|||:|:.
Human   332 RDGTAPPPQSPGSPGTG--------QDEEW--SDEESPRKAATGVRVRALYDYAGQEADELSFRA 386

  Fly   461 GDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            |:...|:.:|||||||:|:: :||:|||||||||
Human   387 GEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	105/255 (41%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	31/52 (60%)
PACSIN3	NP_001171903.1	BAR	16..273	CDD:416402	105/256 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..184		12/28 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..364		16/130 (12%)
		SH3	365..420	CDD:418401	33/54 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159242
Domainoid	1	1.000	222	1.000	Domainoid score	I2594
eggNOG	1	0.900	-	-		E1_KOG2856
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1836
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm40674
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23065
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900