DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synd and Pacsin1

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_058990.1	Gene:	Pacsin1 / 29704	RGDID:	3247	Length:	441	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	199/490 - (40%)
Similarity:	283/490 - (57%)	Gaps:	59/490 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DQLLQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEK 71
            |:..:..:|||||.||||||.|||:||::|||||...:||||.|||.||:.|..|:|:|.:||||
  Rat     6 DEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLIEK 70

  Fly    72 GPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLEDL 135
            ||:||:.|.||..::||::::|::|.::|::|.|:...::|.|||:.||..:| ..||.|:.||.
  Rat    71 GPQYGSLERAWGAMMTEADKVSELHQEVKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDG 135

  Fly   136 FKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQ 200
            |:||||||||.:.::|.||..||.|||.|:.|..:|.|:..:.|::|:|.||:.|:|.|.:..||
  Rat   136 FRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQ 200

  Fly   201 KCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIY 265
            |.:||||:.:.::.|....|:|.|..|||:||.||:.||.|.||:|.::...|:|.:..|...:|
  Rat   201 KTQEKYEKVLEDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVY 265

  Fly   266 EEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQR 330
            .|....|..||.|:||:|:.:..|..|.||||.|.|:..:....| ..|.|:...|....|.|..
  Rat   266 RELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTA-AKKEKQPKKAEGAALSNAT 329

  Fly   331 PVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATATAAAT 395
            ...|                                       :||:|....:|:......|.||
  Rat   330 GAVE---------------------------------------STSQAGDRGSVSSYDRGQAYAT 355

  Fly   396 AASAASNRNSSVTN-GNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFK 459
            ..|...:.|....| .||  .||||:::.:              ||.|:|||||:|.|.|||:||
  Rat   356 EWSDDESGNPFGGNEANG--GANPFEDDAK--------------GVRVRALYDYDGQEQDELSFK 404

  Fly   460 QGDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            .||...||.:|||||||:||: :|::|||||||||
  Rat   405 AGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	120/255 (47%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	34/52 (65%)
Pacsin1	NP_058990.1	F-BAR_PACSIN1	16..273	CDD:153364	120/256 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..380		23/111 (21%)
		SH3 domain	382..441		38/72 (53%)
		SH3_PACSIN1-2	385..440	CDD:212931	37/55 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353261
Domainoid	1	1.000	225	1.000	Domainoid score	I2447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1760
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm44810
orthoMCL	1	0.900	-	-		OOG6_104815
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910