DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synd and cdc15

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_593322.1	Gene:	cdc15 / 2541975	PomBaseID:	SPAC20G8.05c	Length:	927	Species:	Schizosaccharomyces pombe

Alignment Length:	502	Identity:	91/502 - (18%)
Similarity:	185/502 - (36%)	Gaps:	96/502 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DSFW--EPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGT 77
            |:||  |.........|.:....:...:.:...:||.||:.||..|:..:....::    ||.|:
pombe    24 DNFWGSEDAGMDALMSRTKSSLSVLESIDEFYAKRASIEREYASKLQELAASSADI----PEVGS 84

  Fly    78 TEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLMQIKERK-----DLEDLFK 137
            |......:.||:..::..|        .:|:.||.|..:......:.|.:::|     .:|:|::
pombe    85 TLNNILSMRTETGSMAKAH--------EEVSQQINTELRNKIREYIDQTEQQKVVAANAIEELYQ 141

  Fly   138 KAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKC 202
            |.    ..|...:.:.|..|..:|....|...|.:      .::..::.|.:.::::....|:|.
pombe   142 KK----TALEIDLSEKKDAYEYSCNKLNSYMRQTK------KMTGRELDKYNLKIRQAALAVKKM 196

  Fly   203 REKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEE 267
            ..:|.:....:......:|:..|.|.:..|..|:.||:|.|..::...:.:....|:. .:..|:
pombe   197 DAEYRETNELLLTVTREWIDRWTEVCDAFQHIEEYRLEFLKTNMWAYANIISTACVKD-DESCEK 260

  Fly   268 FSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQRPV 332
            ...|:.|.:..:|:.....|.|....:  |...|:.:.|::........:.:..||
pombe   261 IRLTLENTNIDEDITQMIQNEGTGTTI--PPLPEFNDYFKENGLNYDIDQLISKAP--------- 314

  Fly   333 AEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTS--------------------- 376
                  .||.::|....:::|:|..:|::.:.:.:.|.||...|
pombe   315 ------SYPYSSSRPSASASLASSPTRSAFRPKTSETVSSEVVSSPPTSPLHSPVKPVSNEQVEQ 373

  Fly   377 --EAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPF-------------------- 419
              |.:.|..|.....|.:.....:.:|.|..|||:...:|.|.|.
pombe   374 VTEVELSIPVPSIQEAESQKPVLTGSSMRRPSVTSPTFEVAARPLTSMDVRSSHNAETEVQAIPA 438

  Fly   420 -----DEEEEWDESDNVLV-DNGEPGVPVKALYDYEGAESDELTFKQ 460
                 .|.:|...|:|.:. ||.:..:..:......|:.|..|:|.:
pombe   439 ATDISPEVKEGKNSENAITKDNDDIILSSQLQPTATGSRSSRLSFSR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	48/261 (18%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	4/20 (20%)
cdc15	NP_593322.1	F-BAR_PombeCdc15_like	28..263	CDD:153335	46/257 (18%)
cdc15	NP_593322.1	SH3	869..925	CDD:214620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010