DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and FNBP1

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_011516701.1	Gene:	FNBP1 / 23048	HGNCID:	17069	Length:	650	Species:	Homo sapiens

Alignment Length:	650	Identity:	116/650 - (17%)
Similarity:	221/650 - (34%)	Gaps:	195/650 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKW--GELIEKGPEYGTTEA 80
            |:  .:....|..:.|..:.....:.::||.:||..|||.||..|||:  .:..::..||..|..
Human     8 WD--QFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSC 70

  Fly    81 -AWKGVLTESERISDVHMKIKDNLCNDV-------NSQIKTWQKENYHHTLMQIKERKDLEDLFK 137
             |:...|.|....:..|..|.:|:.:.:       ..::|..:|.|:|..              :
Human    71 KAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG--------------R 121

  Fly   138 KAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKC 202
            |||:.......::|.:|..:...||....|.......:||.:::...|:|...:.|......:..
Human   122 KAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDS 186

  Fly   203 REKYEQAIAEIT-KYNSVYIEDMTSVFEKCQTFE-----------KTRLQFFKEILFNVHSCLD- 254
            :..|...:.:.. :.:..|...:.::|:|.|..|           ||..:..::::..:..|||
Human   187 KADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDG 251

  Fly   255 -LTKVQSLPQ---------------------IYEEFS---------HTINNA--DQQKDLKWWSN 286
             :...:|:.|                     .:|:::         ::::|:  :.:.|||:...
Human   252 IVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGK 316

  Fly   287 NHGINMAMNWP----------------------------------------------SFVEYTEE 305
            :.|    ..||                                              .|.|:...
Human   317 SKG----KLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTS 377

  Fly   306 ------FRDIAKGNKS----KE----------------------ALPAAPITLINQRP------- 331
                  ||.:.:|.:|    ||                      .|.|.|....|..|
Human   378 KPKIHCFRSLKRGTQSFCFHKELMKRTIGKPTYAFEARDYVLSLKLGATPEDFSNLPPEQRRKKL 442

  Fly   332 ------VAEDVHQEYPQTNSLKKNTSTL---SSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGA 387
                  :.:::.:|..|.:::.|.....   ..:...||:..::|....::.....:|....|..
Human   443 QQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWL 507

  Fly   388 ATATAAATAASAASNRNS---------SVTNGNGKVDANP---FDEEEEWDESDNVLV------- 433
            |.......|.|..:.|.|         :|.|.....:::|   :.||:..:....||.
Human   508 AEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESSPDGSYTEEQSQESEMKVLATDFDDEF 572

  Fly   434 DNGEPGVPV----KALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMN-GRVGLYPANYVE 493
            |:.|| :|.    ||||.:||.....::..:|:....:|::...||.:.|.| ...|..|.:|||
Human   573 DDEEP-LPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVE 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	55/307 (18%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	16/56 (29%)
FNBP1	XP_011516701.1	F-BAR_FBP17	5..257	CDD:153360	52/264 (20%)
		HR1_FBP17	435..511	CDD:212019	10/75 (13%)
		SH3_FBP17	582..637	CDD:213004	16/54 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940