DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Synd and Itsn2

DIOPT Version :9

Sequence 1:NP_001262786.1 Gene:Synd / 42467 FlyBaseID:FBgn0053094 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_001185897.1 Gene:Itsn2 / 20403 MGIID:1338049 Length:1685 Species:Mus musculus


Alignment Length:690 Identity:132/690 - (19%)
Similarity:233/690 - (33%) Gaps:237/690 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 GNYKRTTKRIEDGYKLCNDLQ----QLIQERADIEKGYAKSLRTWSKKW-GELIEKGPEYGTTEA 80
            |.:::.:.|::| .::....|    :::.::.|:|....|.|:...|:: .:||...||......
Mouse   501 GKHQQISGRLQD-VQIRKQTQKTELEVLDKQCDLEIMEIKQLQQELKEYQNKLIYLVPEKQLLNE 564

  Fly    81 AWKGVL---TESERISDVHMKI--KDNLCNDVNSQIKTWQKEN---------------------- 118
            ..|.:.   |....||.:|.|.  |:.||..:..|:...:||.                      
Mouse   565 RIKNMQLSNTPDSGISLLHKKSSEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGSMDDC 629

  Fly   119 -----------YHHTLMQIKERKD--------LEDLFK----KAQKPWAKLLAKVEKAKADYHSA 160
                       .::..:.:||.::        ||.|.|    |.::...|.|.:::|.|.:..:|
Mouse   630 VLQCLLSLLSCLNNLFLLLKELRESYNTQQLALEQLHKIKRDKLKEIERKRLEQIQKKKLEDEAA 694

  Fly   161 CKTERSATNQERNANADSSLSPDQVKKMHDRVQ------KTKDQVQKCREKYEQAIAEITKYNSV 219
            .|.::...|..|     .|:..::.:| ..|:|      ||:::.:|...|..:..:.:..|.::
Mouse   695 RKAKQGKENLWR-----ESIRKEEEEK-QKRLQEEKSQDKTQEEERKAEAKQSETASALVNYRAL 753

  Fly   220 Y-------------IEDMTSVFEK--------------------CQTFEKT----RLQFFKEILF 247
            |             ..|:..|.||                    |...||.    :....|:.|.
Mouse   754 YPFEARNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKVLSSEKALSPKKALL 818

  Fly   248 NVHSCLDLTKVQSLPQI----YEEFSH---TINNADQQK-----------------------DLK 282
            .....|..|...|.|..    |...|.   |:|...|||                       :||
Mouse   819 PPTVSLSATSTSSQPPASVTDYHNVSFSNLTVNTTWQQKSAFTRTVSPGSVSPIHGQGQAVENLK 883

  Fly   283 -------------------------------WWSNN-HGINMAMNWPSFVEYTEEFRDIAKGNKS 315
                                           ||... ||   ...|     :.:.:..:..||:.
Mouse   884 AQALCSWTAKKENHLNFSKHDVITVLEQQENWWFGEVHG---GRGW-----FPKSYVKLIPGNEV 940

  Fly   316 KEALPAAPITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVK---------SEIATTQS 371
            :...|.|....:.::|.:    ..||.|::.........::.|.:||:         .||..||.
Mouse   941 QRGEPEALYAAVTKKPTS----TAYPVTSTAYPVGEDYIALYSYSSVEPGDLTFTEGEEILVTQK 1001

  Fly   372 S-------------------VTTSEAKT--SAAVAGAAT---ATAAATAASAASNRN-------- 404
            .                   |...:.:.  :|:.:||:.   ..|..|:|.|||...        
Mouse  1002 DGEWWTGSIGERTGIFPSNYVRPKDQENFGNASKSGASNKKPEIAQVTSAYAASGTEQLSLAPGQ 1066

  Fly   405 -----SSVTNG--NGKVDANPFDEEEEWDESDNV--LVDNGEPGVP-------VKALYDYEGAES 453
                 ...|:|  .|::.|.....::.|..:.:|  |..:.|..:|       |.|:|||.....
Mouse  1067 LILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNE 1131

  Fly   454 DELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYVE 493
            |||.|.:|.:...: ::|:..|.:|..||..||:|:|||:
Mouse  1132 DELNFSKGQLINVM-NKDDPDWWQGETNGLTGLFPSNYVK 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SyndNP_001262786.1 F-BAR_PACSIN 17..272 CDD:153339 65/355 (18%)
SH3_PACSIN 441..493 CDD:212777 21/58 (36%)
Itsn2NP_001185897.1 EH 15..107 CDD:197477
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..242
EH 238..317 CDD:197477
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..382
Smc 350..>747 CDD:224117 48/252 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..742 7/26 (27%)
SH3_Intersectin2_1 747..803 CDD:212921 7/55 (13%)
INTAP 806..883 CDD:374674 13/76 (17%)
SH3_Intersectin2_2 883..934 CDD:212923 6/58 (10%)
SH3_Intersectin2_3 973..1024 CDD:212925 8/50 (16%)
SH3_Intersectin2_4 1045..1103 CDD:212927 12/57 (21%)
SH3_Intersectin2_5 1118..1171 CDD:212929 21/54 (39%)
RhoGEF 1202..1381 CDD:366202
PH_13 1400..1554 CDD:374702
C2_Intersectin 1543..1677 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.