Protein Alignment Synd and toca-1

DIOPT Version :9

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_741723.1
• Gene: toca-1 / 180492
• WormBaseID: WBGene00017298
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 608
• Identity: 118/608 - (19%)
• Similarity: 210/608 - (34%)
• Gaps: 159/608 - (26%)

  Fly    15 DSFW-EPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTT 78
            |..| :.|.....|.:   |..|...:....:|||.||..|:..|:..|||....::...|...:
 Worm     8 DQLWDQQGTLNEYTGK---GIDLLERIMAYSKERASIELEYSSKLKALSKKTAMKMKSESELWNS 69

  Fly    79 EAAWKG---VLTESERISDVHMKIKDNLCNDV--------------NSQIKTWQKENYHHTLMQI 126
            .:..||   |:.....::..|..|.:||.:.|              ..|::: ...|....|..:
 Worm    70 VSYVKGFHDVIAGIVPVATQHELIAENLKSAVIPFTTQKIAEYRVAKKQLES-DNSNLGKQLRMV 133

  Fly   127 -----KERKDLEDLFK----------KAQKPWAKLLAKVEKAKADYHSAC-KTERS--------- 166
                 |..|:....:|          ||:|.......::||.|.:|...| ..|.|
 Worm   134 IDEMAKSHKEYVKCYKETEAAMLKYAKAEKNMDISRLELEKTKNNYQQKCGMLEESKQTYAVMTT 198

  Fly   167 ATNQERNANADSSLSP--DQVKKMH-DRVQKTKDQVQKCREKYEQAIAEI--------------- 213
            ..|:|::|:.|..|..  |..||:| :|:..|.:.:.||.|. |..:.:|
 Worm   199 KANEEQSAHYDRKLPQLLDNYKKLHTNRILDTVEILSKCVEA-ESCVNQIIASCHNDMRRDIGLI 262

  Fly   214 --TKYNSVYIEDMTS--------VFEKC-------------------------QTFEK------- 236
              ::..::.:|:|.|        |||..                         .|.:|
 Worm   263 DPSRDANLVVENMKSGHPVPQPFVFEDLGHPQDRSSFMGGGASGPAGSMDGMDATMKKGGTLMSK 327

  Fly   237 -----TRLQFFKEILF---NVHSCLDLTKVQSLP--QIYEEFSHTINNADQQKDLKWWSNNHGIN 291
                 .|.|...:..|   ......|.....:||  |...:.:..|::.:::|| :...:..|::
 Worm   328 NGKGVARKQSMHQKFFGGGTADKKTDSGDYGTLPPQQRARKIAGKISDLEKEKD-RATQSREGVS 391

  Fly   292 MAMNWPSFVEYTEEFRDIAK-GNKSKEALPAAPITLINQRPVAEDVHQEYPQTNSLKKNTSTLSS 355
                     :....:|:..| ||.|.           ....:|:..|:....:|.::|....|..
 Worm   392 ---------KMQAAYRENPKLGNPSD-----------CDAQLAQYGHEIDALSNQIQKFKILLDD 436

  Fly   356 VSSRASVKSEIATT--QSSVTTSEAKTSAAVAGAATAT-----AAATAASAASNRNSSVTNGNGK 413
            |:::.......||:  .|....|....|:|.:|..:..     |..|.......|..|.:..||.
 Worm   437 VNAQLGAGGLSATSVGGSDTPPSIRSVSSASSGVTSRVNTINDAHRTNGGVGGGRRESFSGSNGG 501

  Fly   414 VDANP------FDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDE 472
            .|.:|      ...:|.::|..|.....||    ..|.:.::||:...:..:..:....:|.::.
 Worm   502 SDTDPTINGNGHGRDELYEECSNPNPVLGE----AIAQFAFDGAQDGTIRMEANEKLWLIEKDEG 562

  Fly   473 QGWCKGRM--NGRVGLYPANYVE 493
            .||.:.|.  |...|..|::|::
 Worm   563 DGWTRVRKENNSADGFVPSSYLK 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	71/367 (19%)
		SH3_PACSIN	441..493	CDD:212777	11/53 (21%)
toca-1	NP_741723.1	F-BAR_CIP4-like	8..259	CDD:153337	57/255 (22%)
		HR1_CIP4-like	362..438	CDD:212009	15/96 (16%)
		SH3_CIP4-like	532..586	CDD:212844	11/54 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940