Protein Alignment Synd and itsn-1

DIOPT Version :9

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001299978.1
• Gene: itsn-1 / 178491
• WormBaseID: WBGene00006405
• Length: 1087
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 111/543 - (20%)
• Similarity: 195/543 - (35%)
• Gaps: 156/543 - (28%)

  Fly    10 LQAGSDSFWEPGNYKRTTKRIED--------GYKLCNDLQQLIQE-----RADIEKGYAKSLRTW 61
            |:.|:    ||.......|..||        |.......:::::|     ||::||   |.....
 Worm   275 LEPGA----EPPQKSPAPKTFEDKRQDNLSKGQAELERRRRVLEEEEQRRRAEVEK---KEREEE 332

  Fly    62 SKKWGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQ--IKTWQKENYHHTLM 124
            :||..|..||                  ||.::|..:.      ::..|  |:..::|......:
 Worm   333 AKKNRERQEK------------------ERQAEVERQA------ELERQRIIEAQREEEEKKRRL 373

  Fly   125 QIKERKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACK---TERSATNQERNANADSSLSPDQVK 186
            :::.|::.::..:|.|         :||||.......|   .||.|..|:|......     |::
 Worm   374 EMERRREEDEKMRKVQ---------MEKAKVKQMQNQKQQENERLAQRQQREKTLQF-----QLQ 424

  Fly   187 KMHDRVQKTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHS 251
            .:.::|...:..:.|.:|    |:||:|.    :||.|.|..:     ||
 Worm   425 ALDEKVIDVEVDIGKAKE----AVAEVTG----FIERMRSTRD-----EK--------------- 461

  Fly   252 CLDLTKVQSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSK 316
               :.:::.|.:..::|...|.           |...|..:.....:..|.|:...::....:.:
 Worm   462 ---VARIKELQETNQKFQTAIE-----------SQELGHQLLQKQSAHKETTQRKSELEALRRKR 512

  Fly   317 EALPAAPITLINQRPVAEDV--------HQEYPQTNSLKKN-----TSTLSS-VSSRASVKSEI- 366
            :|:          |...||.        .:.|.||..||.|     |...|. |:.|...::..
 Worm   513 DAI----------RKAIEDAALELSTEKEKSYNQTEILKTNKEKYKTDVYSKLVAKREEYRNSFE 567

  Fly   367 ----ATTQSSVTTSEAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVD------------ 415
                |.|.:.....|.:..:|.|.||.|.|.|.|.:..:...::..:..|:.|
 Worm   568 LLVHAQTHARSKIGEFEAKSAPASAAPAPAPAPAPTTTNGFPANFNDAFGEFDKTDASQRFDADF 632

  Fly   416 -----ANPFDEEEEWDESDNVLVD----NGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDE- 470
                 |:||.:..:........||    |.......:||:.:|....|||:|:.|||....:..
 Worm   633 GATSTADPFAQIAQAPAHSKGAVDQSAFNIHDTYKCRALFAFEARSEDELSFEPGDVIIVFQSHA 697

  Fly   471 DEQGWCKGRMNGRVGLYPANYVE 493
            .|.||..|::..:||.:|..:||
 Worm   698 AEPGWRAGQLREKVGWFPEAFVE 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	52/272 (19%)
		SH3_PACSIN	441..493	CDD:212777	17/52 (33%)
itsn-1	NP_001299978.1	EH	4..93	CDD:197477
		EH	12..80	CDD:238009
		EH	169..259	CDD:197477
		EH	180..246	CDD:238009
		DUF4515	387..578	CDD:291649	49/256 (19%)
		LCD1	390..>429	CDD:286837	11/43 (26%)
		ATP-synt_B	<423..544	CDD:304375	29/172 (17%)
		SH3_Intersectin_1	667..721	CDD:212770	19/54 (35%)
		SH3_Intersectin_2	786..838	CDD:212771
		SH3	889..938	CDD:214620
		SH3_Intersectin_4	965..1021	CDD:212773
		SH3	1028..1085	CDD:214620

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030