DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Synd and Itsn1

DIOPT Version :9

Sequence 1:NP_001262786.1 Gene:Synd / 42467 FlyBaseID:FBgn0053094 Length:495 Species:Drosophila melanogaster
Sequence 2:XP_006522994.1 Gene:Itsn1 / 16443 MGIID:1338069 Length:1743 Species:Mus musculus


Alignment Length:515 Identity:109/515 - (21%)
Similarity:188/515 - (36%) Gaps:156/515 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 ERISDVHMKIKDNLCN-DV-NSQIKTWQKENYHHTLMQIKERKDLEDLFKKAQKPWAKLLAKVEK 152
            |::.:|..:.:..|.. || |:|:|..::   .|:..|:::::.||....| ||...:...::||
Mouse   607 EQLDEVERETRSKLQEIDVFNNQLKELRE---IHSKQQLQKQRSLEAARLK-QKEQERKSLELEK 667

  Fly   153 AKADYHSACKTERSATNQERNANADSSLSPDQ---VKKMH--DRVQKTKDQVQKCREKYEQAIAE 212
            .|.|      .:|..  |||:......:..::   .:|.|  ||: |.:|.|:| :|..|:|..|
Mouse   668 QKED------AQRRV--QERDKQWLEHVQQEEQPRPRKPHEEDRL-KREDSVRK-KEAEERAKPE 722

  Fly   213 ITKYNSVYIEDMTSVFEKCQ------------TFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIY 265
            :.       :..:.:|...|            |.||..|..         |..:..||.....:|
Mouse   723 MQ-------DKQSRLFHPHQEPAKLATQAPWSTTEKGPLTI---------SAQESVKVVYYRALY 771

  Fly   266 --EEFSH---TINNAD------------QQKDLKWWSNNHGINMAMNW-PSFVEYTEEFRDIAKG 312
              |..||   ||...|            |..:..|....  :.....| |:  .|.|:..:    
Mouse   772 PFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPA--NYAEKIPE---- 828

  Fly   313 NKSKEALPAAPITLINQRPVAEDVHQEYP--------QTNSLKKNTSTLSSV-SSRASVKSEIAT 368
              ::...||.|:|.:...|..:...:|.|        :.::...|.:..||. .|.::.|.|  |
Mouse   829 --NEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSSNEKPE--T 889

  Fly   369 TQSSVTTSEAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDA------NPF----DEEE 423
            .......::...:...||.....:|.|.|:|..:..|.|.....||:.      .|:    |...
Mouse   890 DNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHL 954

  Fly   424 EWDESDNVLV-------------------------------------DNG--------------- 436
            .:::||.:.|                                     |.|               
Mouse   955 NFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTESPASLKRVASPA 1019

  Fly   437 -EPGVPVK---ALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYV 492
             :|.:|.:   |:|.||.:|..:|||:||||....:.:.:  |..|.:..:.|::|:|||
Mouse  1020 AKPAIPGEEFIAMYTYESSEQGDLTFQQGDVIVVTKKDGD--WWTGTVGDKSGVFPSNYV 1077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SyndNP_001262786.1 F-BAR_PACSIN 17..272 CDD:153339 48/205 (23%)
SH3_PACSIN 441..493 CDD:212777 20/55 (36%)
Itsn1XP_006522994.1 EH 39..132 CDD:197477
PLN02983 <155..226 CDD:215533
EH 238..333 CDD:197477
PTZ00121 <355..739 CDD:173412 37/152 (24%)
SH3 766..825 CDD:388381 12/62 (19%)
INTAP 825..939 CDD:374674 24/121 (20%)
SH3_Intersectin1_2 939..990 CDD:212922 5/50 (10%)
SH3_Intersectin1_3 1028..1079 CDD:212924 19/52 (37%)
SH3_Intersectin1_4 1096..1160 CDD:212926
SH3_Intersectin1_5 1180..1233 CDD:212928
RhoGEF 1260..1443 CDD:238091
PH_13 1462..1615 CDD:374702
C2_Intersectin 1604..1738 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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