DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and Pacsin2

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_038934232.1	Gene:	Pacsin2 / 124461	RGDID:	69411	Length:	529	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	214/477 - (44%)
Similarity:	301/477 - (63%)	Gaps:	19/477 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTTEAAWKGV 85
            ||||||.|||:||::||.||...:.|||.|||.||:.|..|:::|.:|:||||:|||.|.||..|
  Rat    65 GNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAV 129

  Fly    86 LTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKERKDLEDLFKKAQKPWAKLLAK 149
            ::|:||:|::|:::|.:|.|:...:||.||||.:|..:| ..||.|:.||.|:||||||||.|.:
  Rat   130 MSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKE 194

  Fly   150 VEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQVQKCREKYEQAIAEIT 214
            |:.||..:|:|||.|:.|.::|.|:.||.||:|:|:||:.|:::|.|..|.|.::|||:|:.|:.
  Rat   195 VDAAKKAHHTACKEEKLAVSREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKALKELD 259

  Fly   215 KYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKVQSLPQIYEEFSHTINNADQQK 279
            :....|:|:|..|||:||.||:.||:||:|:|..|...|||:.|.|...||.|...:|..||..:
  Rat   260 QTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKGIYRELEQSIKAADAVE 324

  Fly   280 DLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEALPAAPITLINQRPVAEDVHQEYPQTN 344
            ||:|:..|||..||||||.|.|::.:........:.|:|.....:|.|||  ..:...|..|.:|
  Rat   325 DLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKAADGVTLTGINQ--TGDQSGQNKPSSN 387

  Fly   345 -SLKKNTSTLSSVSSRASVKSEIATTQSSVTTSE-AKTSAAVAGAATATAAATAASAASNRNSSV 407
             |:..|.:..:.:.|..:...:...|.|||:..| .|.....:...|....|..:...||...|.
  Rat   388 LSVPSNPAQSTQLQSSYNPFEDEDDTGSSVSEKEDIKAKNVSSYEKTQNYPADWSDDESNNPFSS 452

  Fly   408 TNGNGKVDANPFDEEEEWDESDNVLVDNGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDE 472
            |:.||  |:|||||:          ..:|.. |.|:|||||||.|.|||:||.||...|:|||||
  Rat   453 TDANG--DSNPFDED----------TTSGTE-VRVRALYDYEGQEHDELSFKAGDELTKIEDEDE 504

  Fly   473 QGWCKGRM-NGRVGLYPANYVE 493
            |||||||: :|:||||||||||
  Rat   505 QGWCKGRLDSGQVGLYPANYVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	123/251 (49%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	38/52 (73%)
Pacsin2	XP_038934232.1	F-BAR_PACSIN2	63..318	CDD:153363	123/252 (49%)
Pacsin2	XP_038934232.1	SH3_PACSIN1-2	472..527	CDD:212931	41/55 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353259
Domainoid	1	1.000	225	1.000	Domainoid score	I2447
eggNOG	1	0.900	-	-		E1_KOG2856
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21414
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1760
OMA	1	1.010	-	-		QHG54548
OrthoDB	1	1.010	-	-		D432948at33208
OrthoFinder	1	1.000	-	-		FOG0001073
OrthoInspector	1	1.000	-	-		otm44810
orthoMCL	1	0.900	-	-		OOG6_104815
Panther	1	1.100	-	-	O	PTHR23065
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X728
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770