Protein Alignment Synd and PACSIN2

DIOPT Version :10

• Sequence 1: NP_001262786.1
• Gene: Synd / 42467
• FlyBaseID: FBgn0053094
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_001336898.1
• Gene: PACSIN2 / 11252
• HGNCID: 8571
• Length: 488
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 227/514 - (44%)
• Similarity: 312/514 - (60%)
• Gaps: 50/514 - (9%)

  Fly     1 MSHHSDDQL-LQAGSDSFWEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKK 64
            ||...||.: ::..||||||.||||||.|||:||::||:||...:.|||.|||.||:.|..|:::
Human     1 MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARR 65

  Fly    65 WGELIEKGPEYGTTEAAWKGVLTESERISDVHMKIKDNLCNDVNSQIKTWQKENYHHTLM-QIKE 128
            |.:|:||||:|||.|.||...::|:||:|::|:::|.:|.||...:||.||||.:|..:| ..||
Human    66 WRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKE 130

  Fly   129 RKDLEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQ 193
            .|:.||.|:||||||||.|.:||.||..:|:|||.|:.|.::|.|:.||.||:|:|:||:.|:::
Human   131 TKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIE 195

  Fly   194 KTKDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEILFNVHSCLDLTKV 258
            |.|..|.|.:||||:::.|:.:....|:|:|..|||:||.||:.||:||:|:|..|...|||:.|
Human   196 KCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNV 260

  Fly   259 QSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSF--VEYTEEFRDIAKGNKSKEALPA 321
            .....||.:...:|..||..:||:|:..|||..||||||.|  .|::.:........:.|:|...
Human   261 AGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEDEEWSADLNRTLSRREKKKATDG 325

  Fly   322 APITLINQRPVAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSV-----------TT 375
            ..:|.|||..     .|..|     .|.:|||:..|:.|    :.|.:|||.           |.
Human   326 VTLTGINQTG-----DQSLP-----SKPSSTLNVPSNPA----QSAQSQSSYNPFEDEDDTGSTV 376

  Fly   376 SE---AKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVDNGE 437
            ||   .|.....:...|.:.....:...||...|.|:.||  |:||||             |:..
Human   377 SEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANG--DSNPFD-------------DDAT 426

  Fly   438 PG--VPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRM-NGRVGLYPANYVE 493
            .|  |.|:|||||||.|.|||:||.||...|:||||||||||||: ||:||||||||||
Human   427 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVE 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	125/255 (49%)
		SH3_PACSIN	441..493	CDD:212777	39/52 (75%)
PACSIN2	NP_001336898.1	F-BAR_PACSIN2	18..275	CDD:153363	125/256 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..428		35/140 (25%)
		NPF	<340..430	CDD:406900	29/113 (26%)
		NPF1	364..366		0/1 (0%)
		NPF2	407..409		0/1 (0%)
		NPF3	419..421		1/1 (100%)
		SH3_PACSIN1-2	431..486	CDD:212931	42/55 (76%)