DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Synd and Trip10

DIOPT Version :9

Sequence 1:NP_001262786.1 Gene:Synd / 42467 FlyBaseID:FBgn0053094 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_001229318.1 Gene:Trip10 / 106628 MGIID:2146901 Length:603 Species:Mus musculus


Alignment Length:647 Identity:109/647 - (16%)
Similarity:218/647 - (33%) Gaps:228/647 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 WEPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGPEYGTTEAAW 82
            |:  .::...:..:.|..|.:...:.::|||::|:.|||.||:..||:   :.|.|.....|..:
Mouse     8 WD--QFEVLERHTQWGLDLLDKYVKFVKERAEVEQAYAKQLRSLVKKY---LPKRPTKDDPEVKF 67

  Fly    83 KGVLTESERISDVHMKIKD--------------NLCNDVNSQIKTWQKENYHHTLMQIKERKDLE 133
                ::.:....:..::.|              .:|.::....:..::|...|.....:.::.||
Mouse    68 ----SQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLE 128

  Fly   134 DLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSLSPDQVKKMHDRVQKTKDQ 198
            :.||           ::|.:|..:...|:....|.:.....:.|.:.:...|:|...:.......
Mouse   129 NGFK-----------QLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHM 182

  Fly   199 VQKCREKYEQAIAEITKYN----SVYIEDMTSVFEKCQTFEK---TRL--------QFFKEILFN 248
            .::.:.:|   .|::.::|    ..|...|..:|:|.|..::   |||        :...:::..
Mouse   183 AEESKNEY---AAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELQVVPI 244

  Fly   249 VHSCLDLTKV-----------QSLPQI------------YEEFSHTINNA---------DQQKDL 281
            :..||:..||           |.|.::            :|:||..||..         |.:.:|
Mouse   245 IGKCLEGMKVAAESVDAKNDSQVLIELHKSGFARPGDLEFEDFSQVINRVPSDSSLGTPDGRPEL 309

  Fly   282 KWWSNNHGINMAMNWP------------------------------------------------- 297
            :..|:.   :.|..||                                                 
Mouse   310 RAASSR---SRAKRWPFGKKNKPRPPSLSLLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVKP 371

  Fly   298 ---SFVEY--------TEEF--------------------RDIAKGNKSKEALPAAPITLINQRP 331
               ||..:        ||:|                    |::.|....:|||..          
Mouse   372 RLASFRSFRGGRGTVATEDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKK---------- 426

  Fly   332 VAEDVHQEYPQTNSLKKNTSTLSSVSSRASVKSEIATTQSSVTTSEAKTSAAVAGAATA------ 390
             .:||:::.||             :...||::..||.|..::...:.:.....|..|.|      
Mouse   427 -MKDVYEKTPQ-------------MGDPASLEPRIAETLGNIERLKLEVQKYEAWLAEAESRVLS 477

  Fly   391 ----------------TAAATAASAASNRNSSVTNGNGKVDANPFDEEE-----EWDESDNVLVD 434
                            |.|...:|::|..:.|..|.....:..|.:.::     |:||      |
Mouse   478 NRGDSLSRHARPPDPPTTAPPDSSSSSTNSGSQDNKESSSEEPPSEGQDTPIYTEFDE------D 536

  Fly   435 NGEPGVPV---KALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCK-GRMNGRVGLYPANYV 492
            ..||..|:   .|:|.:||:....::..:|:....:|::...||.: .|..|..|..|.:|:
Mouse   537 FEEPASPIGQCVAIYHFEGSSEGTVSMSEGEDLSLMEEDKGDGWTRVRRKQGAEGYVPTSYL 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SyndNP_001262786.1 F-BAR_PACSIN 17..272 CDD:153339 52/305 (17%)
SH3_PACSIN 441..493 CDD:212777 14/56 (25%)
Trip10NP_001229318.1 Required for podosome formation and interaction with AKAP9 and microtubules. /evidence=ECO:0000250 1..117 20/117 (17%)
Required for translocation to the plasma membrane in response to insulin 1..117 20/117 (17%)
F-BAR_CIP4-like 5..257 CDD:153337 47/271 (17%)
Interaction with PDE6G. /evidence=ECO:0000250 293..603 55/339 (16%)
Interaction with CDC42. /evidence=ECO:0000250 293..539 39/278 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..358 6/65 (9%)
HR1_CIP4_FNBP1L 395..475 CDD:212018 17/103 (17%)
Required for interaction with FASLG and localization to lysosomes. /evidence=ECO:0000250 471..603 28/134 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..541 12/69 (17%)
Interaction with DNM2 and WASL. /evidence=ECO:0000269|PubMed:16418535 487..543 13/61 (21%)
Interaction with DNM1 and WASL. /evidence=ECO:0000250 532..603 20/73 (27%)
Required for podosome formation. /evidence=ECO:0000250 540..603 15/59 (25%)
Interaction with WAS. /evidence=ECO:0000250 546..603 13/53 (25%)
SH3_CIP4-like 546..600 CDD:212844 13/53 (25%)
Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250 548..603 13/51 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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