DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synd and pstpip1

DIOPT Version :9

Sequence 1:	NP_001262786.1	Gene:	Synd / 42467	FlyBaseID:	FBgn0053094	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_031754976.1	Gene:	pstpip1 / 100379705	XenbaseID:	XB-GENE-960789	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	111/513 - (21%)
Similarity:	190/513 - (37%)	Gaps:	147/513 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DSFW------EPGNYKRTTKRIEDGYKLCNDLQQLIQERADIEKGYAKSLRTWSKKWGELIEKGP 73
            ::||      ..| |:...:|:.||.|:|.|::.|:::||..|:.|.|.|...:||.|
Frog     8 NAFWCTDLTLNTG-YEIILQRMLDGRKMCKDVEDLLKQRAQAEEKYGKELVQIAKKAG------- 64

  Fly    74 EYGTTE-----AAWKGVLTESERISDVHMKIKDNLCNDVNS--QIKTWQKENYHHTLMQIKERKD 131
              |.||     .:::.:..:.|.|.:.|:::...|..::.|  :.:..|||          .||.
Frog    65 --GQTEINKLQESFETLKNQIENIGNSHIQLAVTLREEIQSLEEFRERQKE----------VRKK 117

  Fly   132 LEDLFKKAQKPWAKLLAKVEKAKADYHSACKTERSATNQERNANADSSL-SPDQVKKMHDRVQKT 195
            .|:..::.||....|..|...:|..|...|   |.|.:.|:|.....:| :|.|::|..::.:..
Frog   118 YENAMERLQKNKVSLYKKTMDSKKSYEQRC---REAEDAEQNYERLVALGNPKQIEKSQNKAKHC 179

  Fly   196 KDQVQKCREKYEQAIAEITKYNSVYIEDMTSVFEKCQTFEKTRLQFFKEIL------FNVHSCLD 254
            ||..::....|:..|..:.|....:..:.::..|..|..|..|:...:..|      |:.....|
Frog   180 KDAAEEADRLYKNNIELLEKARIEWETEHSNTCEAFQLQETDRISILRNSLWVQCNHFSSQCVRD 244

  Fly   255 LTKVQSLPQIYEEFSHTINNADQQKDLKWWSNNHGINMAMNWPSFVEYTEEFRDIAKGNKSKEAL 319
                   .::.||...|:...|...::.:               |::           :|:...:
Frog   245 -------DEMMEEVRQTLEQCDVTTEIDF---------------FIQ-----------SKTTGKV 276

  Fly   320 PAAPITLINQRPVAEDVHQEY-----PQ----------TNSLKKNTSTLSSVSSRASVKSEIATT 369
            |.||:           :::.|     |:          :|.:.|..|.|.| ....|.|: :...
Frog   277 PPAPV-----------LYEGYCNGFLPESSIGPNMQGGSNKMMKRISNLLS-GCGGSTKN-LTEF 328

  Fly   370 QSSVTTSEAKTSAAVAGAATATAAATAASAASNRNSSVTNGNGKVDANPFDEEEEWDESDNVLVD 434
            |:...|..||.....|...||..|..                         |.|::
Frog   329 QAGFNTPAAKEETVYASIPTAHVAQA-------------------------EVEDY--------- 359

  Fly   435 NGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYV 492
                    ..||||....||||....|||...||:.|: ||.....||::||.|.:|:
Frog   360 --------SVLYDYSAQNSDELDITAGDVVRVLEEGDD-GWWTVERNGKIGLVPGSYL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synd	NP_001262786.1	F-BAR_PACSIN	17..272	CDD:153339	63/274 (23%)
Synd	NP_001262786.1	SH3_PACSIN	441..493	CDD:212777	22/52 (42%)
pstpip1	XP_031754976.1	BAR	15..256	CDD:416402	62/270 (23%)
pstpip1	XP_031754976.1	SH3_PSTPIP1	358..410	CDD:212758	22/69 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D727724at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920