DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdSS and ADE12

DIOPT Version :9

Sequence 1:	NP_650918.1	Gene:	AdSS / 42466	FlyBaseID:	FBgn0027493	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_014179.1	Gene:	ADE12 / 855501	SGDID:	S000005164	Length:	433	Species:	Saccharomyces cerevisiae

Alignment Length:	429	Identity:	242/429 - (56%)
Similarity:	320/429 - (74%)	Gaps:	10/429 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSV 90
            |:||||:|||||||||:||:|....|||.||.||||||||:|.:|.::|||:||||:||..|.::
Yeast     2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNL 66

  Fly    91 IGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAE-----KGGKSL 150
            :|||||||:||.|.|:...|||||::..:||.:|.||||||||||..|.::|.|     |.||::
Yeast    67 LGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNI 131

  Fly   151 GTTKKGIGPAYSSKATRNGIRVGELLGD----FNLFSEKFKSIVATHVRLFPSINVDVEAELARY 211
            |||.|||||.||:||:|:|:||..|:.|    :..|..::|.::.|..:.:.....|.||:||.|
Yeast   132 GTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEY 196

  Fly   212 KDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLP 276
            |...::::|:|.|::.|:|.|:...|.||||||||.||||||||||||||||..|||||||||:|
Yeast   197 KKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIP 261

  Fly   277 PQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSL 341
            |:||.|:.|||||||||||:|||||||||:.|:.|||.|.|.||||.|||||||||:.:|||::|
Yeast   262 PRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTL 326

  Fly   342 VNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAELGNIEVEYAVLPGWQTSTEEV 406
            :||||.:.:||||:|||..||.|.::| ...|:|||.||..:..||.:||||.|||||.....::
Yeast   327 INGYTSLNITKLDVLDTFKEIPVGISY-SIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKI 390

  Fly   407 RNFKELPENAQSYVRFLESELSVPVRWVGVGKGRESIIN 445
            ..:::|||||:.|::::|..:.|||.|||.|..|||:::
Yeast   391 TKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLH 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdSS	NP_650918.1	Adenylsucc_synt	28..444	CDD:279098	241/424 (57%)
ADE12	NP_014179.1	Adenylsucc_synt	4..428	CDD:395577	241/424 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343447
Domainoid	1	1.000	498	1.000	Domainoid score	I51
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111992
Inparanoid	1	1.050	500	1.000	Inparanoid score	I209
Isobase	1	0.950	-	0	Normalized mean entropy	S352
OMA	1	1.010	-	-		QHG60682
OrthoFinder	1	1.000	-	-		FOG0001592
OrthoInspector	1	1.000	-	-		oto98944
orthoMCL	1	0.900	-	-		OOG6_100659
Panther	1	1.100	-	-	LDO	PTHR11846
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1038
SonicParanoid	1	1.000	-	-		X1000
TreeFam	0	0.000	Not matched by this tool.
	14	13.880