Protein Alignment Adss and ADSS2

DIOPT Version :10

• Sequence 1: NP_650918.1
• Gene: Adss / 42466
• FlyBaseID: FBgn0027493
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: NP_001117.2
• Gene: ADSS2 / 159
• HGNCID: 292
• Length: 456
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 275/451 - (60%)
• Similarity: 340/451 - (75%)
• Gaps: 11/451 - (2%)

  Fly     2 SASATNGTHYEQLHQGRTKMYKSKVDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTV 66
            ::|..||    ...:.|.:...::|.|||||||||||||||||:||.|.||||||||||||||||
Human    10 ASSLPNG----DCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTV 70

  Fly    67 VANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKN--EAKGLQHLENRLIISDRAHL 129
            |.:..|:||||||||::|....:.||||||||||.||:|..||  :.|||:..|.|||||||||:
Human    71 VVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHI 135

  Fly   130 VFDFHQHVDGMQE---AEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVA 191
            ||||||..||:||   .|:.||:||||||||||.|||||.|:|:|:.:|:.||:.|||:||.:..
Human   136 VFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLAN 200

  Fly   192 THVRLFPSINVDVEAELARYKDYADKVRPYVKDTICFLHTALRN-GKTILVEGANAAMLDIDFGT 255
            .:..::|::.:|:|.||.:.|.|.:|::|.|:|.:.||:.||.. .|.|||||||||:|||||||
Human   201 QYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGT 265

  Fly   256 YPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEVGV 320
            ||:||||||::|||.||||:|||.:|||.|||||||||||.|.|||||.|:||:||||||.|.||
Human   266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGV 330

  Fly   321 TTKRKRRCGWLDIPLLKYTSLVNGYTCICLTKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAE 385
            ||.|||||||||:.||||..::||:|.:.||||||||...||||.||||. :||.:.|.|.....
Human   331 TTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKL-DGEIIPHIPANQEV 394

  Fly   386 LGNIEVEYAVLPGWQTSTEEVRNFKELPENAQSYVRFLESELSVPVRWVGVGKGRESIINV 446
            |..:||:|..||||.|.....|.|||||.|||:||||:|.||.:||:|:||||.|||:|.:
Human   395 LNKVEVQYKTLPGWNTDISNARAFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQL 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adss	NP_650918.1	Adenylsucc_synt	28..444	CDD:459912	269/421 (64%)
ADSS2	NP_001117.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		4/17 (24%)
		Adenylsucc_synt	32..453	CDD:459912	269/421 (64%)