DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syp and rbm47

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_005168416.1	Gene:	rbm47 / 562991	ZFINID:	ZDB-GENE-030131-9612	Length:	601	Species:	Danio rerio

Alignment Length:	592	Identity:	222/592 - (37%)
Similarity:	307/592 - (51%)	Gaps:	83/592 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RQKSRASQQGVAAPATVKG-PDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVPGNGCEVF 209
            :..|...|.....|..|.| |:|..:..::||:||.:....||||| ||||.|:|..|..|||:|
Zfish    22 KSSSGHPQHHCTVPEGVAGAPNEAALVSLMERSGYGMVQENGQRKY-GPPPGWQGTSPPRGCEIF 85

  Fly   210 CGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRT 274
            .||||:|:|||||:|:||:.|.|:::||||| ..|.|||||||.:|.:..|..|||:||:||||.
Zfish    86 VGKIPRDVYEDELVPVFESVGRIYEMRLMMD-FDGKNRGYAFVMYTQKHEAKRAVRELNNFEIRP 149

  Fly   275 GKKIGVTISFNNHRLFVGNIPKNRDRDELIEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYES 339
            |:.:||..|.:|.|||:|.|||.:.|:|::||.||...|:.:||:|:|..||.|||||.|:||||
Zfish   150 GRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVSKVTEGVLDVIVYASAADKMKNRGFAFVEYES 214

  Fly   340 HKAASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQ 404
            |:||::|:|:|..|||::||..|.||||:|:.:.||..|..||:||||||..:.||:.|::.|.|
Zfish   215 HRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETSEEILRQTFGQ 279

  Fly   405 Y--GKVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRA-- 465
            :  |.|||||||:||||:||..||.||.||..|||.||..|.|||:||| |.||::.....:|
Zfish   280 FNPGCVERVKKIRDYAFVHFASRDDAVVAMDNLNGTEIEGSRIEVTLAK-PVDKEQYTRYQKASK 343

  Fly   466 --------RERRMMQMMQARPGIVGFETLSPYRNL-SPTHPSIMSLTPMRPGAR--MPLRTPIPR 519
                    ...:...:.|..|..:.:... ||..| .|.....:....:|...|  ...|.|.||
Zfish   344 GTAAATTVESTQQSYVYQCDPYTLAYYGY-PYNTLIGPNRDYFIKAGTVRGRGRAGASSRGPGPR 407

  Fly   520 EYDYFYDFFGFSDYRQGGSFGNNV--SYYDDMYRWIDGDYNYYD-------YPNGGGGGSGGGGG 575
                       ..|..|.|.|..:  .|::...:..|..|....       .|.|
Zfish   408 -----------GSYLGGYSAGRGIYSRYHEGKTKLPDKPYEIMSNLELAAVNPVG---------- 451

  Fly   576 SVSGGTVLPLSAGGSQNSPMASGQRSARGSASG-----------------PSASPSLMGVGRGHG 623
             :..|| :.|.|.|:|...:.|...:.:....|                 |:|:.:...|.....
Zfish   452 -IKPGT-MALPALGAQYPTVFSAAPATKLMEEGKIHPVEHLINPLALQHDPTAASATAAVIPAVS 514

  Fly   624 ITVP-RGRVVGQRGSISRLGAQTVPQAAGA---------AAAAGQAAAAVAQRGATGQGAPAATG 678
            ...| :||.:....:::. ..|.:|.||.:         ||.|..|..|..|:.|   ...||.|
Zfish   515 TPPPFQGRPITPVYAMAH-NIQRIPAAAASLYGAGYMPIAAHANTATLAALQKNA---AVAAAYG 575

  Fly   679 GFRGVLP 685
            |:.|.:|
Zfish   576 GYAGYMP 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	46/77 (60%)
		RRM2_hnRNPR_like	286..367	CDD:240696	45/80 (56%)
		RRM3_hnRNPR_like	381..452	CDD:240697	44/72 (61%)
rbm47	XP_005168416.1	hnRNP-R-Q	34..601	CDD:273732	220/580 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920