DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syp and CG3335

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	104/524 - (19%)
Similarity:	188/524 - (35%)	Gaps:	170/524 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SRTILKTPSSFRTPSPIPSCSKMAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGK 85
            ||..:::.::..:.....|.||.|:.:.:.||.:.:|                     :::.|.|
  Fly    70 SRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEK---------------------EREAAAK 113

  Fly    86 LDEIYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYL----CGVMKT-- 144
            ..|..|..|....:..::.|...|:.|      ...:|||::     :||..|    .|:.|.
  Fly   114 AKESEKKKKKDKVDKVDQILSRHKDDP------EFQEFLEAH-----DKSRTLWGNDLGINKNRE 167

  Fly   145 -------YRQKSRASQ--QGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGN 200
                   .:::|||::  .||.|.|    .|||
  Fly   168 NEEEDDEEQEESRAARDDSGVDADA----GDED-------------------------------- 196

  Fly   201 VPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVR 265
              |:|.|.       |..||.            | :|...|::......:.:..|:.||
  Fly   197 --GSGDEA-------DEEEDT------------D-KLAEKPISDLEYMKSLMATTSGEA------ 233

  Fly   266 QLNDFEIRTGKKIGVTISFNNHRLF---VGNIPKNRDRDELIEEFSKHAPGLYEVIIYSSPDDKK 327
                    |.||.......:|..||   :.|:|.|..|.|:::.|....|  |.|.:.|
  Fly   234 --------TAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKP--YSVRLPS------ 282

  Fly   328 KNRGFCFLEYESHK--AASLAKRRLGTGRIKVWGCDI-------------------IVD-----W 366
            |..|||::.:::.|  |..:.|.:......:|:..|.                   .||     |
  Fly   283 KVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSDFTEKNKVTKASKSGQPLAPAAVDAGNAKW 347

  Fly   367 ADPQEE-PDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERV--------KKIKDYAFIHF 422
            ...|:. ..|..:|:...::.|||....:|:.|::.|||:|.|..|        :|||.:..:.:
  Fly   348 KHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLDKLTRKIKGFGTVTY 412

  Fly   423 EDRDSAVEAMRGLNGKEIGASNIEVSLAK-----PPSDKKKKEEILRARERRMMQMMQARPGIVG 482
            ...:.|::|...|:|.:.....:.:..:|     |..|..:.:..|..:|::.:::.:.....:|
  Fly   413 MMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDENDASLSFKEKKALKLKKNAQKPIG 477

  Fly   483 FETL 486
            :.||
  Fly   478 WNTL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	14/77 (18%)
		RRM2_hnRNPR_like	286..367	CDD:240696	24/109 (22%)
		RRM3_hnRNPR_like	381..452	CDD:240697	19/83 (23%)
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008	2/6 (33%)
		RRM_SF	250..314	CDD:302621	18/71 (25%)
		RRM3_RBM19	362..440	CDD:241011	18/77 (23%)
		RRM4_RBM19	552..623	CDD:241013
		RRM	<638..845	CDD:223796
		RRM5_RBM19_like	679..760	CDD:240764
		RRM6_RBM19	785..864	CDD:241015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840