DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syp and dnd1

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_997960.1	Gene:	dnd1 / 373074	ZFINID:	ZDB-GENE-030828-4	Length:	411	Species:	Danio rerio

Alignment Length:	392	Identity:	101/392 - (25%)
Similarity:	172/392 - (43%)	Gaps:	83/392 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVP 202
            :.|.|...:|:    .|.:..|..:|     .:::.::|...||....||||||||||.|:|..|
Zfish     1 MVGDMDAQQQE----LQQILNPQKLK-----SLQEWMQRNSITLTQVNGQRKYGGPPPGWQGPAP 56

  Fly   203 GNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQL 267
            |:|||||..:||.|:|||.|||||::.|.|::.||||: .:|..||:|:..:.:...|..||..|
Zfish    57 GSGCEVFISQIPNDVYEDRLIPLFQSIGTIYEFRLMMN-FSGQTRGFAYAKYGDPLTASAAVTTL 120

  Fly   268 NDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDELIEEFSKHAPGLYEVIIYSSPDDKKKNRGF 332
            :.:.:..|..:.|..|....:|.:|::|.:.:..:|:......:.|:.:|::  .|...|.....
Zfish   121 HQYRLPEGGCLTVRRSTEKRQLRLGDLPVSMNESKLLMVLQMLSDGVEDVLL--KPPGPKGKEVV 183

  Fly   333 CFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWAD----------PQEEPDEQTMSKVKVLYVR 387
            ..:.|.||.|||:||:.|.......:|..|.|.|..          |||:      |.|..|.::
Zfish   184 ALVNYTSHYAASMAKKVLVEAFRNRYGISITVRWTSFSKSKRVEDTPQED------SCVTPLVLK 242

  Fly   388 NLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFE--DRDSAVEAMRGLNGKEIGASNIEVSLA 450
            .|::.                         :.:|::  ...|.:...|.:.|
Zfish   243 PLSKP-------------------------SLLHYDVPAHQSLLPLFRAVGG------------- 269

  Fly   451 KPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHPSIMSLTPMRPGARMPLRT 515
              |:..::::|::            .:|.|:....|.|..::......:..| |:||...|..::
Zfish   270 --PTTSEQRDEMI------------PQPTIMSRNELIPQSSIRQRDEMVPQL-PIRPRDGMAPQS 319

  Fly   516 PI 517
            ||
Zfish   320 PI 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	32/77 (42%)
		RRM2_hnRNPR_like	286..367	CDD:240696	20/80 (25%)
		RRM3_hnRNPR_like	381..452	CDD:240697	7/72 (10%)
dnd1	NP_997960.1	RRM_SF	59..136	CDD:302621	32/77 (42%)
		RRM2_DND1	138..220	CDD:240937	21/83 (25%)
		DND1_DSRM	323..403	CDD:291380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0117
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820