DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syp and Syncrip

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001382580.1	Gene:	Syncrip / 363113	RGDID:	1305683	Length:	623	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	331/737 - (44%)
Similarity:	412/737 - (55%)	Gaps:	151/737 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKE 110
            |||     ..:..|.......:|::..||:.||.:|||.||||||..|.:||::|||||::||||
  Rat     8 GNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKE 67

  Fly   111 FPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILE 175
            |..||||.||.||.:|:|.||.||||:||||||||||:.:   ||.....:.|||||.|||.:||
  Rat    68 FNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREK---QGTKVADSSKGPDEAKIKALLE 129

  Fly   176 RTGYTLDVTTGQRKYGGPPPH--WEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLM 238
            ||||||||||||||||||||.  :.|..|..|.|:|.||||:|::||||:||||..|.|||||||
  Rat   130 RTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLM 194

  Fly   239 MDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDEL 303
            |||:||.|||||||||..:|||..||:..|:.|||:||.|||.||..|:|||||:|||::.::::
  Rat   195 MDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQI 259

  Fly   304 IEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWAD 368
            :|||||...||.:||:|..||||||||||||||||.||.|:.|:|||.:|::||||....|:|||
  Rat   260 LEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWAD 324

  Fly   369 PQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMR 433
            |.|:||.:.|:|||||:||||...|:|:.|::.|.|:||:|||||:||||||||::||.||:||.
  Rat   325 PIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAME 389

  Fly   434 GLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHPS 498
            .:|||::...|||:..||||..|:|:.:..|...:..|              ...|....|.|
  Rat   390 EMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQM--------------YDDYYYYGPPH-- 438

  Fly   499 IMSLTPMRP-------GARMPLRTPIPREYDY--FYDFFGFS--DYRQGGSFGNNVSYYDDMYRW 552
                  |.|       |.|.....| |..|.|  :||::|:.  :||.|         |:|.|
  Rat   439 ------MPPPTRGRGRGGRGGYGYP-PDYYGYEDYYDYYGYDYHNYRGG---------YEDPY-- 485

  Fly   553 IDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMG 617
                |.|.|:..|..|..|                            |.|||      |:||
  Rat   486 ----YGYEDFQVGARGRGG----------------------------RGARG------AAPS--- 509

  Fly   618 VGRGHGITVPRGRV-VGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFR 681
              ||.|...||||. ..|||.           ...|....|....|..|||...:||....||..
  Rat   510 --RGRGAAPPRGRAGYSQRGG-----------PGSARGVRGARGGAQQQRGRGVRGARGGRGGNV 561

  Fly   682 GVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPL- 745
            |                       ||||.||  .|..|.|||..     |..:|||.|:.||||
  Rat   562 G-----------------------GKRKADG--YNQPDSKRRQT-----NNQNWGSQPIAQQPLQ 596

  Fly   746 -----GTNG-----EQWYMDTF 757
                 |..|     |::|.|||
  Rat   597 GGDHSGNYGYKSENEEFYQDTF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	52/77 (68%)
		RRM2_hnRNPR_like	286..367	CDD:240696	48/80 (60%)
		RRM3_hnRNPR_like	381..452	CDD:240697	41/70 (59%)
Syncrip	NP_001382580.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6680
eggNOG	1	0.900	-	-		E1_KOG0117
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1102
OMA	1	1.010	-	-		QHG49453
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	1	1.000	-	-		otm45375
orthoMCL	1	0.900	-	-		OOG6_104511
Panther	1	1.100	-	-	O	PTHR21245
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880