Protein Alignment Syp and Syncrip

DIOPT Version :10

• Sequence 1: NP_001262777.1
• Gene: Syp / 42460
• FlyBaseID: FBgn0038826
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001382580.1
• Gene: Syncrip / 363113
• RGDID: 1305683
• Length: 623
• Species: Rattus norvegicus
• Alignment Length: 737
• Identity: 331/737 - (44%)
• Similarity: 412/737 - (55%)
• Gaps: 151/737 - (20%)

  Fly    46 GNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKE 110
            |||     ..:..|.......:|::..||:.||.:|||.||||||..|.:||::|||||::||||
  Rat     8 GNG-----TEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKE 67

  Fly   111 FPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILE 175
            |..||||.||.||.:|:|.||.||||:||||||||||:.:   ||.....:.|||||.|||.:||
  Rat    68 FNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREK---QGTKVADSSKGPDEAKIKALLE 129

  Fly   176 RTGYTLDVTTGQRKYGGPPPH--WEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLM 238
            ||||||||||||||||||||.  :.|..|..|.|:|.||||:|::||||:||||..|.|||||||
  Rat   130 RTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLM 194

  Fly   239 MDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDEL 303
            |||:||.|||||||||..:|||..||:..|:.|||:||.|||.||..|:|||||:|||::.::::
  Rat   195 MDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQI 259

  Fly   304 IEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWAD 368
            :|||||...||.:||:|..||||||||||||||||.||.|:.|:|||.:|::||||....|:|||
  Rat   260 LEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWAD 324

  Fly   369 PQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMR 433
            |.|:||.:.|:|||||:||||...|:|:.|::.|.|:||:|||||:||||||||::||.||:||.
  Rat   325 PIEDPDPEVMAKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAME 389

  Fly   434 GLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHPS 498
            .:|||::...|||:..||||..|:|:.:..|...:..|              ...|....|.|
  Rat   390 EMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQM--------------YDDYYYYGPPH-- 438

  Fly   499 IMSLTPMRP-------GARMPLRTPIPREYDY--FYDFFGFS--DYRQGGSFGNNVSYYDDMYRW 552
                  |.|       |.|.....| |..|.|  :||::|:.  :||.|         |:|.|
  Rat   439 ------MPPPTRGRGRGGRGGYGYP-PDYYGYEDYYDYYGYDYHNYRGG---------YEDPY-- 485

  Fly   553 IDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMG 617
                |.|.|:..|..|..|                            |.|||      |:||
  Rat   486 ----YGYEDFQVGARGRGG----------------------------RGARG------AAPS--- 509

  Fly   618 VGRGHGITVPRGRV-VGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFR 681
              ||.|...||||. ..|||.           ...|....|....|..|||...:||....||..
  Rat   510 --RGRGAAPPRGRAGYSQRGG-----------PGSARGVRGARGGAQQQRGRGVRGARGGRGGNV 561

  Fly   682 GVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPL- 745
            |                       ||||.||  .|..|.|||..     |..:|||.|:.||||
  Rat   562 G-----------------------GKRKADG--YNQPDSKRRQT-----NNQNWGSQPIAQQPLQ 596

  Fly   746 -----GTNG-----EQWYMDTF 757
                 |..|     |::|.|||
  Rat   597 GGDHSGNYGYKSENEEFYQDTF 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	NURR_Syncrip-like	68..150	CDD:410953	53/81 (65%)
		hnRNP-R-Q	153..>563	CDD:273732	216/422 (51%)
Syncrip	NP_001382580.1	NURR_hnRNPQ	23..107	CDD:410954	53/83 (64%)
		hnRNP-R-Q	103..615	CDD:273732	272/632 (43%)