DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syp and syncrip

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_999861.1	Gene:	syncrip / 326663	ZFINID:	ZDB-GENE-030131-4862	Length:	630	Species:	Danio rerio

Alignment Length:	728	Identity:	326/728 - (44%)
Similarity:	411/728 - (56%)	Gaps:	132/728 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 ADDRGDGERTED-------------YPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALK 109
            |.:..:|..|||             :..|||.||.:|||.||||||..|.:||::|||||::|||
Zfish     2 ATEHINGNGTEDAMDTAAAVTHSDHFNTLLEAGLPQKVAEKLDEIYLAGLVAHSDLDERAIEALK 66

  Fly   110 EFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKIL 174
            ||..:|||.||.||.||:|.||.||||:||||||||||:.:   ||.....:.|||||.|||.:|
Zfish    67 EFNEEGALQVLIQFKESDLSHVQNKSAFLCGVMKTYRQREK---QGTKVVESTKGPDEAKIKILL 128

  Fly   175 ERTGYTLDVTTGQRKYGGPPPH--WEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRL 237
            |||||||||||||||||||||.  :.|..|..|.|:|.||||:|::||||:|.||..|.||||||
Zfish   129 ERTGYTLDVTTGQRKYGGPPPESVYTGAQPTVGTEIFVGKIPRDLFEDELVPQFEKAGPIWDLRL 193

  Fly   238 MMDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDE 302
            ||||::|.||||||:||..:|||..||:..|:.|||.||.|||.||..|:|||||:|||::.:::
Zfish   194 MMDPLSGLNRGYAFLTFCTKEAAQEAVKLCNNHEIRPGKHIGVCISVANNRLFVGSIPKSKTKEQ 258

  Fly   303 LIEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWA 367
            ::|||||...||.:||:|..||||||||||||||||.||.|:.|:|||.:|::||||..:.|:||
Zfish   259 IVEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNLVTVEWA 323

  Fly   368 DPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAM 432
            ||.|:||.:.|:|||||:||||...|:|:.|::.|.|:|.:|||||:|||||:||.|||.||:|:
Zfish   324 DPIEDPDPEVMAKVKVLFVRNLANSVTEEILEKAFGQFGNLERVKKLKDYAFVHFNDRDGAVKAL 388

  Fly   433 RGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYRNLSPTHP 497
            ..:||||:...:||:..||||..|:|:.:..|...:..|              ...|....|..
Zfish   389 TEMNGKELEGEHIEIVFAKPPDQKRKERKAQRQAAKTQM--------------YDDYYYYGPPQ- 438

  Fly   498 SIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFSDYRQ--GGSFGNNVSYYDDMYRWIDGDYNYY 560
                   |.|.||...|......|.|..|::|:.||..  |..:.|....|||.|      :.|.
Zfish   439 -------MPPPARGRGRGASRGGYSYPPDYYGYEDYYDYYGYDYHNYRGGYDDPY------FGYD 490

  Fly   561 DYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSASPSLMGVGRGHGIT 625
            |:.....|  .||.||..|||                              ||:     ||.|.:
Zfish   491 DFQAPARG--RGGRGSARGGT------------------------------SPA-----RGRGAS 518

  Fly   626 VPRGRVVGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPAATGGFRGVLPTRPSA 690
            .||||.             ..||..||.|..|      |.||..|       |...|||   |..
Zfish   519 APRGRA-------------GFPQRGGAGAGPG------ASRGLRG-------GARGGVL---PRG 554

  Fly   691 RGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPLPQQPL------GTNG 749
            ||.:..:..:...|.||||.||  .|..|.|||...     ..:|||.|:.||||      |..|
Zfish   555 RGVRGARGGRGGNVGGKRKADG--YNQPDSKRRQTI-----NQNWGSQPIAQQPLQGGDHSGNYG 612

  Fly   750 -----EQWYMDTF 757
                 :::|.|:|
Zfish   613 YKSDNQEFYQDSF 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	49/77 (64%)
		RRM2_hnRNPR_like	286..367	CDD:240696	48/80 (60%)
		RRM3_hnRNPR_like	381..452	CDD:240697	39/70 (56%)
syncrip	NP_999861.1	hnRNP-R-Q	103..622	CDD:273732	267/622 (43%)
		RRM1_hnRNPQ	161..239	CDD:240927	49/77 (64%)
		RRM2_hnRNPQ	241..325	CDD:240933	50/83 (60%)
		RRM3_hnRNPQ	337..408	CDD:240939	39/70 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6729
eggNOG	1	0.900	-	-		E1_KOG0117
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1150
OMA	1	1.010	-	-		QHG49453
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	1	1.000	-	-		otm25257
orthoMCL	1	0.900	-	-		OOG6_104511
Panther	1	1.100	-	-	O	PTHR21245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9312
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870