Protein Alignment Syp and A1CF

DIOPT Version :9

• Sequence 1: NP_001262777.1
• Gene: Syp / 42460
• FlyBaseID: FBgn0038826
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001185748.1
• Gene: A1CF / 29974
• HGNCID: 24086
• Length: 602
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 219/615 - (35%)
• Similarity: 292/615 - (47%)
• Gaps: 157/615 - (25%)

  Fly   152 SQQGVAAPATVKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEGNVPGNGCEVFCGKIPKD 216
            :....|.|...||  .:.::.|:.:|  .|:...||||||||||.|:...|..|||:|.||:|:|
Human    14 ASMSTAIPGLKKG--NNALQSIILQT--LLEKENGQRKYGGPPPGWDAAPPERGCEIFIGKLPRD 74

  Fly   217 MYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVT 281
            ::|||||||.|..|.|:::|:||| ..|.|||||||||:|:..|.||::|||::|||.|:.:||.
Human    75 LFEDELIPLCEKIGKIYEMRMMMD-FNGNNRGYAFVTFSNKVEAKNAIKQLNNYEIRNGRLLGVC 138

  Fly   282 ISFNNHRLFVGNIPKNRDRDELIEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLA 346
            .|.:|.|||||.|||.:.|:|::.|..|...|:.:||:|.|..||.|||||.|:|||||:||::|
Human   139 ASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRGFAFVEYESHRAAAMA 203

  Fly   347 KRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQY--GKVE 409
            :|:|..|||::||..|.||||:|:.|.||.|||.||:||||||....||:.::::|...  |.||
Human   204 RRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLMLSTSEEMIEKEFNNIKPGAVE 268

  Fly   410 RVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERR--MMQ 472
            |||||:||||:||.:|:.|||||:.||||.:..|.|||:||| |.||.......|....|  |:|
Human   269 RVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIEVTLAK-PVDKDSYVRYTRGTGGRGTMLQ 332

  Fly   473 MMQARPGIVGFETLS--------------PYRNLSPTHPSIMSL-TPMRPG---ARMPLRTPIPR 519
                     |..|.|              |......|:.:|.|| .|...|   .|..:|.|..|
Human   333 ---------GEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLHFPATKGHLSNRAIIRAPSVR 388

  Fly   520 EYDYFYDFFGFSDYRQGGSFGNNVSYYDDMYRWIDGDYNYYDYPNG-----GGGGSG-------G 572
            |.                                     |.:.|.|     |.||.|       |
Human   389 EI-------------------------------------YMNVPVGAAGVRGLGGRGYLAYTGLG 416

  Fly   573 GGGSVSGG-------TVLPLSAGGSQNSPMASGQRSARGSASGP--------------------- 609
            .|..|.|.       .:||    |.:.:||.......:|....|
Human   417 RGYQVKGDKREDKLYDILP----GMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHS 477

  Fly   610 --------------------SASPSLMGVGRGHGITVPR-------GRVVGQRGSISRLGAQTVP 647
                                |.:|::      |..|.|:       .:......::..||   :|
Human   478 AIGQDQRQLFLYKITIPALASQNPAI------HPFTPPKLSAFVDEAKTYAAEYTLQTLG---IP 533

  Fly   648 QAAGAAAAAGQAAAAVAQRGATGQGAPAAT 677
            ...|....|..||||.|   ..|...|.||
Human   534 TDGGDGTMATAAAAATA---FPGYAVPNAT 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	45/77 (58%)
		RRM2_hnRNPR_like	286..367	CDD:240696	44/80 (55%)
		RRM3_hnRNPR_like	381..452	CDD:240697	41/72 (57%)
A1CF	NP_001185748.1	hnRNP-R-Q	29..602	CDD:273732	215/598 (36%)
		RRM1_ACF	63..140	CDD:240930	45/77 (58%)
		RRM2_ACF	142..226	CDD:240934	46/83 (55%)
		RRM3_ACF	231..313	CDD:240942	48/82 (59%)
		DND1_DSRM	455..531	CDD:291380	6/81 (7%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0117
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820