DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syp and hrpr-1

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_493049.2	Gene:	hrpr-1 / 173086	WormBaseID:	WBGene00002000	Length:	611	Species:	Caenorhabditis elegans

Alignment Length:	668	Identity:	257/668 - (38%)
Similarity:	357/668 - (53%)	Gaps:	106/668 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KTPSSFRTPSPIPSCSKMAE--GNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDE 88
            :|.:..:|....|....:||  .||:...: |.|.::......||:|.||:...:...:|..:.|
Worm    15 ETTTEAKTEEAAPVAEVVAEVVTNGDKPAE-NGKTEEPSKYAETENYKKLIGLKMKPALADVVCE 78

  Fly    89 IYKTGKLAHAELDERALDALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQ 153
            ||::|.|...:||:||:|.:....:|.|..:..:...|.|..|:.||.|:..:::::  |.|..|
Worm    79 IYESGLLGPEDLDDRAVDIINSVNLDQAKFIFTEIKNSELFGVATKSLYVTSLIRSF--KDRCRQ 141

  Fly   154 QGVAAPAT---VKGPDEDKIKKILERTGYTLDVTTGQRKYGGPPPHWEG---NVPGNGCEVFCGK 212
            ||.||..:   :.||:...:|.:||.||||::||.||||:|||||.|||   ...|.|.|::.|.
Worm   142 QGAAAVTSGKLINGPELAALKNLLETTGYTIEVTIGQRKFGGPPPDWEGPATGPAGQGHEIYVGH 206

  Fly   213 IPKDMYEDELIPLFENCGIIWDLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKK 277
            ||.|::||.|:||||..|.|||||||||||:|.:|||||||:.|:|.|..|.:..:..||.|||.
Worm   207 IPTDVFEDTLVPLFEKSGKIWDLRLMMDPMSGASRGYAFVTYCNKEDAAAAAKTYDGHEISTGKP 271

  Fly   278 IGVTISFNNHRLFVGNIPKNRDRDELIEEFSKHAPGLYEVIIYSSPDDKK-KNRGFCFLEYESHK 341
            :.|.:|..|.|||:|||||.:.:||::||...||.|:.:||:||.||::| |||||||:::..||
Worm   272 LKVNVSIANTRLFIGNIPKTKSKDEILEELKTHAEGVVDVIVYSVPDNEKIKNRGFCFVDFIDHK 336

  Fly   342 AASLAKRRLGTGRIKVWGCDIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYG 406
            .||..||::...:|:.:..|:.||||:.||||||.|||||||||:||:.:.|:|:||.|.|::|.
Worm   337 TASDIKRKIAQHKIRPFNADVYVDWAEHQEEPDEDTMSKVKVLYIRNIKEAVTEEKLNELFKEYA 401

  Fly   407 KVERVKKIKDYAFIHFEDRDSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMM 471
            .::||||:||||||||.:||..::||...||||:..:.:|.||||||.:|||| .::|.|
Worm   402 SLDRVKKVKDYAFIHFNERDDCLKAMEEWNGKELEGTVVEASLAKPPQEKKKK-PVMRGR----- 460

  Fly   472 QMMQARPGIVGFETLSPYRNLSPTHPSIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFSDYRQG 536
                      ||....   ..:..|           |.|                    ...|.|
Worm   461 ----------GFGGAG---GGAGNH-----------GQR--------------------GGQRGG 481

  Fly   537 GSFGNNV---SYYDDMYRWIDGDYNYYDYPNGGGGGSGG--GGGSVSGGTVLPLSAGGSQNSPMA 596
            |.:|.|.   .||.:.:.      |.||.|...|||.||  |.|:..||      .||....|.|
Worm   482 GQWGGNAGPGGYYPNHFN------NGYDMPMPWGGGYGGDMGYGAYGGG------YGGGYGGPGA 534

  Fly   597 SGQRSARGSA---SGPSASPSLMGVGRGHGITVPRGRVVGQRGSISRLGAQTVPQAAGAAAAAGQ 658
            .|...|.|..   .|...||. .|:|.|.|.   ||...|:.|..:|.|.
Worm   535 YGDFGAYGGGGFRGGMRGSPR-GGMGGGGGF---RGGPPGRGGMANRRGR--------------- 580

  Fly   659 AAAAVAQRGATGQGAPAA 676
                 .:|...|:|.||:
Worm   581 -----GKRPGDGRGGPAS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	43/77 (56%)
		RRM2_hnRNPR_like	286..367	CDD:240696	40/81 (49%)
		RRM3_hnRNPR_like	381..452	CDD:240697	38/70 (54%)
hrpr-1	NP_493049.2	RRM1_hnRNPR_like	199..277	CDD:240695	43/77 (56%)
		RRM2_hnRNPR_like	280..362	CDD:240696	40/81 (49%)
		RRM3_hnRNPR_like	376..445	CDD:240697	36/68 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I5015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136708
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1038
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49453
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	1	1.000	-	-		oto18643
orthoMCL	1	0.900	-	-		OOG6_104511
Panther	1	1.100	-	-	LDO	PTHR21245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9312
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010