DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syp and syncrip

DIOPT Version :9

Sequence 1:	NP_001262777.1	Gene:	Syp / 42460	FlyBaseID:	FBgn0038826	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_002933974.2	Gene:	syncrip / 100144726	XenbaseID:	XB-GENE-920046	Length:	623	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	324/743 - (43%)
Similarity:	409/743 - (55%)	Gaps:	163/743 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERALDALKE 110
            |||     ..:..|......::|....||:.||.:|||.||||||.:|.:.|::|||||::||||
Frog     8 GNG-----TEEPMDTYAAVAQSEHMQTLLDAGLPQKVAEKLDEIYISGLVTHSDLDERAIEALKE 67

  Fly   111 FPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKIKKILE 175
            |..:|||.||.||.:|:|.||.||||:||||||||||:.:   ||.....:.|||||.|||.:||
Frog    68 FNEEGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREK---QGTKVADSSKGPDESKIKALLE 129

  Fly   176 RTGYTLDVTTGQRKYGGPPPHW--EGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIWDLRLM 238
            ||||||||||||||||||||.:  .|..|..|.|:|.||||:|::||||:||||..|.|||||||
Frog   130 RTGYTLDVTTGQRKYGGPPPDFVHTGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGSIWDLRLM 194

  Fly   239 MDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNRDRDEL 303
            |||:||.|||||||||..:|||..||:..|:.|||.||.|||.||..|:|||||:|||::.::::
Frog   195 MDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRPGKHIGVCISVANNRLFVGSIPKSKTKEQI 259

  Fly   304 IEEFSKHAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGCDIIVDWAD 368
            :|||||...||.:||:|..||||||||||||||||.||.|:.|:|||.:|::||||..:.|:|||
Frog   260 VEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVVTVEWAD 324

  Fly   369 PQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDRDSAVEAMR 433
            |.|:||.:.|:|||||:||||...|:|:.|::.|.|:||:|||||:||||||||::|..||:||.
Frog   325 PIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFGQFGKLERVKKLKDYAFIHFDERVGAVKAME 389

  Fly   434 GLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMM---------------QMMQARPGIVGF 483
            .:||||:...|||:..||||..|:|:.:..|...:..|               ...:.|.|..|:
Frog   390 EMNGKELEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDEYYYYGGPHMPPPSRGRGRGGRGGY 454

  Fly   484 ETLSPYRNLSPTHPSIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFS--DYRQGGSFGNNVSYY 546
            ...|.|..                             ||.:||::|:.  :||.|         |
Frog   455 GYPSDYYG-----------------------------YDDYYDYYGYDYHNYRGG---------Y 481

  Fly   547 DDMYRWIDGDYNYYDYPNGGGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPSA 611
            ||.:      |.|.|:..|..|..|                            |.|||      |
Frog   482 DDPF------YGYEDFQVGARGRGG----------------------------RGARG------A 506

  Fly   612 SPSLMGVGRGHGITVPRGRV-VGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAPA 675
            :||     ||.|...||||. ..|||.           ...|..|.|....|..|||...:||..
Frog   507 APS-----RGRGAVPPRGRAGYSQRGG-----------PGSARGARGARGGAQQQRGRGVRGARG 555

  Fly   676 ATGGFRGVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLPL 740
            ..||..|                       ||||.||  .|..|.|||..     |..:|||.|:
Frog   556 GRGGNVG-----------------------GKRKADG--YNQPDSKRRQT-----NNQNWGSQPI 590

  Fly   741 PQQPL------GTNG-----EQWYMDTF 757
            .||||      |..|     :::|.|:|
Frog   591 AQQPLQGGDHSGNYGYKSENQEFYQDSF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syp	NP_001262777.1	RRM1_hnRNPR_like	205..283	CDD:240695	52/77 (68%)
		RRM2_hnRNPR_like	286..367	CDD:240696	48/80 (60%)
		RRM3_hnRNPR_like	381..452	CDD:240697	41/70 (59%)
syncrip	XP_002933974.2	hnRNP_Q_AcD	34..103	CDD:375786	45/68 (66%)
syncrip	XP_002933974.2	hnRNP-R-Q	103..615	CDD:273732	268/638 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1188
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	1	1.000	-	-		otm48453
Panther	1	1.100	-	-	O	PTHR21245
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160