DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha4T1 and PRE6

DIOPT Version :9

Sequence 1:	NP_650910.1	Gene:	Prosalpha4T1 / 42457	FlyBaseID:	FBgn0265606	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_014604.1	Gene:	PRE6 / 854119	SGDID:	S000005398	Length:	254	Species:	Saccharomyces cerevisiae

Alignment Length:	250	Identity:	122/250 - (48%)
Similarity:	168/250 - (67%)	Gaps:	3/250 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRYGRALTIFSPDGHLLQVEYAQEAVRKGSTAVGVRGANCVVLGVEKSSVSEMQEDR-TVRKISM 66
            |.|.|||:|||||||:.|||||.|||::|:.||||:|.||||||.|:.|..::|:.| |..|:|.
Yeast     2 SGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSK 66

  Fly    67 LDRHVALAFAGLTADARILINRGQVECQSHRLNFENQVTLEYITRYLAQLKQKYTQCNGRRPFGI 131
            :|.||.|:|:||.||:||||.:.:||.|||||..|:.||:||:|||:|.::|:|||..|.||||:
Yeast    67 IDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGV 131

  Fly   132 SCLIGGID-ADGSARLFHTEPSGIFHEYKATATGRWANTVREFFEKAYSDHE-VTTKCDAIKLAM 194
            |.||.|.| .|...:|:.||||||:..:.|...||.:.|||||.||.|...| ..|..:.:||.:
Yeast   132 STLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTV 196

  Fly   195 RALLEVTQMSQMRLEVAVLENGKPMKMLDSVVISEIVKIVQNEKELQAKAHKMKR 249
            |:||||.|.....:|:.|::....:..|.|..|::.|..::.||:.|.:..|.|:
Yeast   197 RSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKK 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha4T1	NP_650910.1	PRK03996	5..239	CDD:235192	117/236 (50%)
Prosalpha4T1	NP_650910.1	proteasome_alpha_type_7	5..213	CDD:239724	111/210 (53%)
PRE6	NP_014604.1	proteasome_alpha_type_7	4..215	CDD:239724	111/210 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345390
Domainoid	1	1.000	202	1.000	Domainoid score	I553
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2086
Inparanoid	1	1.050	264	1.000	Inparanoid score	I615
Isobase	1	0.950	-	0	Normalized mean entropy	S208
OMA	1	1.010	-	-		QHG62217
OrthoFinder	1	1.000	-	-		FOG0002043
OrthoInspector	1	1.000	-	-		otm46601
orthoMCL	1	0.900	-	-		OOG6_101207
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1345
TreeFam	1	0.960	-	-
	15	14.710