DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and Cdk4

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	XP_038935924.1	Gene:	Cdk4 / 94201	RGDID:	621120	Length:	313	Species:	Rattus norvegicus

Alignment Length:	227	Identity:	101/227 - (44%)
Similarity:	141/227 - (62%)	Gaps:	12/227 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VQLFDVVISGN-----NLYMIFEYLNMDLKKLMDKKKDVFTP-QLIKSYMHQILDAVGFCHTNRI 126
            |:|.||..:..     .:.::||:::.||:..:||......| :.||..|.|.|..:.|.|.|.|
  Rat    82 VRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCI 146

  Fly   127 LHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWS 191
            :||||||:|:||.:.|.:|||||||||.::..| |.|..||||||||||:||.:. |:|.||:||
  Rat   147 VHRDLKPENILVTSNGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQST-YATPVDMWS 209

  Fly   192 LGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--DFKTKFPRWEGTNMPQP 254
            :||||:||..|:.||.|:||.|||.:||..:..|.|.:||....||  .|..:.||...:.:|:
  Rat   210 VGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFSPRGPRPVQSVVPE- 273

  Fly   255 ITEHEAHELIMSMLCYDPNLRISAKDALQHAY 286
             .|....:|::.||.::|..||||..||||:|
  Rat   274 -MEESGAQLLLEMLTFNPLKRISAFRALQHSY 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	101/227 (44%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	101/227 (44%)
Cdk4	XP_038935924.1	PKc_like	<82..305	CDD:419665	101/227 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810