Protein Alignment Cdk2 and CDKL1

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 120/309 - (38%)
• Similarity: 178/309 - (57%)
• Gaps: 28/309 - (9%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGV-PSTAIREISLLKNLKHPNVV 68
            ::.:::..|||||:||:|:|.|:..|||.||:||. ||.|.:.| ...|:|||.:||.|||||:|
Human     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLKHPNLV 64

  Fly    69 QLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            .|.:|......|:::|||.:..:...:|:.:......|:||...|.|.||.|||.:..:|||:||
Human    65 NLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKP 129

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSE 198
            :|:|:.....|||.|||.||....|...||..|.|.|||:||:|:|...|...||:|::||:|:|
Human   130 ENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE 194

  Fly   199 MIMRRSLFPGDSEIDQLYRIFRTLS--TPD-----ETN--WPGVTQLPD------FKTKFPRWEG 248
            ::....|:||.|::||||.|.:||.  .|.     .||  :.|| ::||      .:.|||
Human   195 LLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV-KIPDPEDMEPLELKFP---- 254

  Fly   249 TNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVA 297
             |:..|     |..|:...|..||..|::.:..|.|.||.|::.::.:|
Human   255 -NISYP-----ALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLA 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	116/294 (39%)
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	116/296 (39%)
		[NKR]KIAxRE	45..51		1/5 (20%)