Protein Alignment Cdk2 and SMK1

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_015379.1
• Gene: SMK1 / 856167
• SGDID: S000006258
• Length: 388
• Species: Saccharomyces cerevisiae
• Alignment Length: 316
• Identity: 104/316 - (32%)
• Similarity: 155/316 - (49%)
• Gaps: 50/316 - (15%)

  Fly    14 IGEGTYGIV--YKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLK-HPNVVQLFD--V 73
            :|:|.||.|  .|.:..|....:|:|||......|.:...||||:..:...| |.|:|.|.|  :
Yeast    44 LGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEI 108

  Fly    74 VISG--NNLYMIFEYLNMDLKKLMDKKKDVFTPQL----IKSYMHQILDAVGFCHTNRILHRDLK 132
            |.|.  :.||...|.::.||.|::..     :.||    ||.:::|||..:.:.|:..::|||||
Yeast   109 VTSSPYDGLYCYQELIDYDLAKVIHS-----SVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLK 168

  Fly   133 PQNLLVDTAGKIKLADFGLARAF--------NVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDI 189
            |.|:|....|.:|:.||||||..        :......|:.|.|.||||||:||..:.||..|||
Yeast   169 PGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDI 233

  Fly   190 WSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKF---PRW---EG 248
            |::|||.:|...|:.:|.|...:.|::.|.:.|.|||:          |...||   ..|   :.
Yeast   234 WAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK----------DILIKFGTIKAWNLGKN 288

  Fly   249 TNMPQ----------PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVD 294
            :|.|.          |...|||..||.|:|.:|...|::.:.|:.|.:...|:..|
Yeast   289 SNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPFLNEVRKPD 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	102/307 (33%)
SMK1	NP_015379.1	Protein Kinases, catalytic domain	37..376	CDD:473864	104/316 (33%)