DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and CDC28

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_009718.3	Gene:	CDC28 / 852457	SGDID:	S000000364	Length:	298	Species:	Saccharomyces cerevisiae

Alignment Length:	296	Identity:	166/296 - (56%)
Similarity:	215/296 - (72%)	Gaps:	8/296 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTILDNFQRAEKIGEGTYGIVYKARSNSTGQD---VALKKIRLEGETEGVPSTAIREISLLKNL 62
            |:..|.|::|.||:||||||:||||.....||.   |||||||||.|.|||||||||||||||.|
Yeast     1 MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKEL 65

  Fly    63 KHPNVVQLFDVVIS-GNNLYMIFEYLNMDLKKLMD--KKKDVFTPQLIKSYMHQILDAVGFCHTN 124
            |..|:|:|:|:|.| .:.||::||:|::|||:.|:  .|.......::|.:|.|:...:.:||::
Yeast    66 KDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSH 130

  Fly   125 RILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDI 189
            |||||||||||||::..|.:||.||||||||.||:||||||:|||||||||:|||.|.||||||.
Yeast   131 RILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDT 195

  Fly   190 WSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQ- 253
            ||:||||:||..|:.:|.|||||||:::|||.|.||:|..||.:..|||||..||:|...::.|
Yeast   196 WSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQV 260

  Fly   254 -PITEHEAHELIMSMLCYDPNLRISAKDALQHAYFR 288
             |..:....:|:..:|.|||..||||:.|..|.||:
Yeast   261 VPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQ 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	165/292 (57%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	161/286 (56%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	161/286 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74409
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
TreeFam	1	0.960	-	-
	10	9.730