Protein Alignment Cdk2 and cdk4

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001071245.2
• Gene: cdk4 / 777730
• ZFINID: ZDB-GENE-060929-974
• Length: 297
• Species: Danio rerio
• Alignment Length: 300
• Identity: 133/300 - (44%)
• Similarity: 187/300 - (62%)
• Gaps: 33/300 - (11%)

  Fly     8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLK---HPNVVQ 69
            ::...:||.|.||.|||||...:||.||||.:|::...:|:|.:.:||::|||.|:   |||:|:
Zfish     9 YEPVAEIGGGAYGTVYKARDRDSGQFVALKSVRVQTNQDGLPLSTVREVALLKRLEQFDHPNIVR 73

  Fly    70 LFDVVIS-----GNNLYMIFEYLNMDLKKLMDKKKDVFTPQL----IKSYMHQILDAVGFCHTNR 125
            |.||..:     ...:.::||:::.||:..::|   |..|.|    |:..|.|:|..:.|.||||
Zfish    74 LMDVCATLRTDQETKVTLVFEHVDQDLRTYLEK---VPAPGLPVDKIRDLMQQLLCGLAFLHTNR 135

  Fly   126 ILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIW 190
            :|||||||:|:||.:.|::|||||||||.::..| |.|..|||||||:||:||.:. |:|.||||
Zfish   136 VLHRDLKPENILVTSRGQVKLADFGLARIYSCHM-ALTPVVVTLWYRSPEVLLQST-YATPVDIW 198

  Fly   191 SLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--DFKTKFPRWEGTNMPQ 253
            |.||||:||..|:.||.||||.|||.:||..:..|.|..||....|.  :|..:.||
Zfish   199 STGCIFAEMFRRKPLFCGDSEADQLGKIFAVIGLPAEDQWPTDVTLSHHNFSPQSPR-------- 255

  Fly   254 PITE------HEAHELIMSMLCYDPNLRISAKDALQHAYF 287
            |||:      .:..||::.||.:||..||||.:||.|.:|
Zfish   256 PITDCVPDITEKGAELLLKMLTFDPLKRISALNALDHPFF 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	132/298 (44%)
cdk4	NP_001071245.2	STKc_CDK4	8..295	CDD:143368	132/298 (44%)