DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk2 and CDKL5

DIOPT Version :10

Sequence 1:NP_524420.1 Gene:Cdk2 / 42453 FlyBaseID:FBgn0004107 Length:314 Species:Drosophila melanogaster
Sequence 2:NP_003150.1 Gene:CDKL5 / 6792 HGNCID:11411 Length:1030 Species:Homo sapiens


Alignment Length:339 Identity:116/339 - (34%)
Similarity:176/339 - (51%) Gaps:41/339 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVV 68
            :::.|:....:|||.||:|.|.|...|.:.||:||.:...|.|.|..|.:||:.:|:.||..|:|
Human     9 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIV 73

  Fly    69 QLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            :|.:.......||::|||:..::.:|:::..:...|:.:|||::|::.|:.:||.|.|:|||:||
Human    74 ELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKP 138

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRA-YTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFS 197
            :|||:.....:||.|||.||..:....| ||..|.|.|||:||:|||.. |...||:||:|||..
Human   139 ENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILG 202

  Fly   198 EMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKF----PRWEG-----TNMPQ 253
            |:...:.||||:||||||:.|.:.|.           .||..:.|.    ||:.|     .|.||
Human   203 ELSDGQPLFPGESEIDQLFTIQKVLG-----------PLPSEQMKLFYSNPRFHGLRFPAVNHPQ 256

  Fly   254 P-------ITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVD------------HVALP 299
            .       |......:|:.::|..||..|...:..|.|..|:..:.:|            ||...
Human   257 SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESS 321

  Fly   300 VDPNAGSASRLTRL 313
            ...|...|.:.|.|
Human   322 TLSNRNQAGKSTAL 335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk2NP_524420.1 STKc_CDK1_CdkB_like 8..287 CDD:270829 108/295 (37%)
CDKL5NP_003150.1 STKc_CDKL5 11..297 CDD:270838 108/297 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..566
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..834
Blue background indicates that the domain is not in the aligned region.

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