Protein Alignment Cdk2 and MAPK3

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_002737.2
• Gene: MAPK3 / 5595
• HGNCID: 6877
• Length: 379
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 109/320 - (34%)
• Similarity: 170/320 - (53%)
• Gaps: 47/320 - (14%)

  Fly     8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIR-LEGETEGVPSTAIREISLLKNLKHPNVVQLF 71
            :.:.:.||||.||:|..|..:.....||:|||. .|.:|  .....:|||.:|...:|.||:.:.
Human    42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT--YCQRTLREIQILLRFRHENVIGIR 104

  Fly    72 DVVISG-----NNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDL 131
            |::.:.     .::|::.:.:..||.||:  |....:...|..:::|||..:.:.|:..:|||||
Human   105 DILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167

  Fly   132 KPQNLLVDTAGKIKLADFGLARAFNVPMRAY----THEVVTLWYRAPEILLGTKFYSTGVDIWSL 192
            ||.|||::|...:|:.||||||..: |...:    |..|.|.|||||||:|.:|.|:..:||||:
Human   168 KPSNLLINTTCDLKICDFGLARIAD-PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV 231

  Fly   193 GCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDE-----------TNWPGVTQLPDFKTK---- 242
            |||.:||:..|.:|||...:|||..|...|.:|.:           .|:  :..||. |||
Human   232 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY--LQSLPS-KTKVAWA 293

  Fly   243 --FPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPV 300
              ||:          ::.:|.:|:..||.::||.||:.::||.|.|..  |:.|....||
Human   294 KLFPK----------SDSKALDLLDRMLTFNPNKRITVEEALAHPYLE--QYYDPTDEPV 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	104/305 (34%)
MAPK3	NP_002737.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		STKc_ERK1_2_like	36..370	CDD:270839	109/320 (34%)
		TXY	202..204		1/1 (100%)