Protein Alignment Cdk2 and MAPK1

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_002736.3
• Gene: MAPK1 / 5594
• HGNCID: 6871
• Length: 360
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 106/305 - (34%)
• Similarity: 162/305 - (53%)
• Gaps: 29/305 - (9%)

  Fly    14 IGEGTYGIVYKARSNSTGQDVALKKIR-LEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISG 77
            ||||.||:|..|..|.....||:|||. .|.:|  .....:|||.:|...:|.|::.:.|::.:.
Human    31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIGINDIIRAP 93

  Fly    78 -----NNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLL 137
                 .::|::.:.:..||.||:  |....:...|..:::|||..:.:.|:..:|||||||.|||
Human    94 TIEQMKDVYIVQDLMETDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL 156

  Fly   138 VDTAGKIKLADFGLARAFNVPMRAY----THEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSE 198
            ::|...:|:.||||||..: |...:    |..|.|.|||||||:|.:|.|:..:||||:|||.:|
Human   157 LNTTCDLKICDFGLARVAD-PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 220

  Fly   199 MIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--------DFKTKFPRWEGTNMPQPI 255
            |:..|.:|||...:|||..|...|.:|.:.:...:..|.        ..|.|.| |   |...|.
Human   221 MLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVP-W---NRLFPN 281

  Fly   256 TEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPV 300
            .:.:|.:|:..||.::|:.||..:.||.|.|..  |:.|....|:
Human   282 ADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE--QYYDPSDEPI 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	102/290 (35%)
MAPK1	NP_002736.3	STKc_ERK1_2_like	19..353	CDD:270839	106/305 (35%)
		TXY. /evidence=ECO:0000269|PubMed:18760948	185..187		1/1 (100%)
		Cytoplasmic retention motif. /evidence=ECO:0000269|PubMed:18760948	318..322		1/3 (33%)
		Nuclear translocation motif. /evidence=ECO:0000269|PubMed:18760948	327..333