Protein Alignment Cdk2 and CDK18

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: XP_054192892.1
• Gene: CDK18 / 5129
• HGNCID: 8751
• Length: 574
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 143/322 - (44%)
• Similarity: 200/322 - (62%)
• Gaps: 35/322 - (10%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            |:.:.:.:|:|||||..|:|.||..|...||||:||||.| ||.|.|||||:||||||||.|:|.
Human   239 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVT 302

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.|::.:..:|.::||||:.|||:.:|...::.:...:|.:|.|:|..:.:||..:|||||||||
Human   303 LHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQ 367

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||::..|::||||||||||.:||.:.|::||||||||.|::|||:..|||.:|:|.:|||..||
Human   368 NLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEM 432

  Fly   200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKT-KFPRWEGTNMPQPITEHE---- 259
            ...|.||||.:..::|:.|||.|.||.|..|||||...:|:| .||.:    :|||:..|.
Human   433 ATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCY----LPQPLINHAPRLD 493

  Fly   260 -------AHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDPNAGSASRLTRLV 314
                   :..|::|:|...|..|.....                 :|| |:||...:|..||
Human   494 TDGIHLLSSLLLVSVLPAGPRERQPKSQ-----------------VPV-PHAGPTPQLLWLV 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	134/290 (46%)
CDK18	XP_054192892.1	Protein Kinases, catalytic domain	236..498	CDD:473864	130/263 (49%)