DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and CDK17

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001163935.1	Gene:	CDK17 / 5128	HGNCID:	8750	Length:	523	Species:	Homo sapiens

Alignment Length:	302	Identity:	148/302 - (49%)
Similarity:	208/302 - (68%)	Gaps:	13/302 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            ::.:.:.||:|||||..|||.||..|...||||:||||.| ||.|.|||||:||||:|||.|:|.
Human   189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVT 252

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.|:|.:..:|.::||||:.|||:.||...::.:...:|.:::|||..:.:||..::||||||||
Human   253 LHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQ 317

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||::..|::||||||||||.:||.:.|::||||||||.|::|||:..|||.:|:|.:||||.||
Human   318 NLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEM 382

  Fly   200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKT-KFPRWEGTNMPQPITEH----- 258
            ...|.||||.:..|:|:.|||.|.||.:..|||::...:||. .||:::    |||:..|
Human   383 ASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK----PQPLINHAPRLD 443

  Fly   259 -EAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALP 299
             |..|||...|.|:...|:||::|::|.|||::....| |||
Human   444 SEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIH-ALP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	144/294 (49%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	141/285 (49%)
CDK17	NP_001163935.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..123
		STKc_PCTAIRE2	185..493	CDD:143377	148/302 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820