Protein Alignment Cdk2 and CDKL3

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: XP_011541731.1
• Gene: CDKL3 / 51265
• HGNCID: 15483
• Length: 619
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 100/310 - (32%)
• Similarity: 155/310 - (50%)
• Gaps: 39/310 - (12%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            ::.::...|:|||:||.|.|.:..:|||.||: ||..|...:.|...|:|||..||...|.|:|.
Human     1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAI-KIFYERPEQSVNKIAMREIKFLKQFHHENLVN 64

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.:|......::::||:::..:...:.........:.::.|:.|||.|:.:.|:|.|:|||:||:
Human    65 LIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPE 129

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYS------------TGV 187
            |:||..:|..||.|||.||....|...||..|.|.||||||::|....|.            ..|
Human   130 NILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKYVYFGILSAFPRPV 194

  Fly   188 DIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLS--TPDETNWPGVTQLPDFKTKFPRWEGTN 250
            |||:|||:..||.......|..|::|.|::|...:.  :|         .|.:..:|.|.:.|..
Human   195 DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSP---------HLQNIFSKSPIFAGVV 250

  Fly   251 MPQPITEHEAH-------------ELIMSMLCYDPNLRISAKDALQHAYF 287
            :||  .:|..:             :::.:.|..||..|||:.|.|.|.||
Human   251 LPQ--VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	98/305 (32%)
CDKL3	XP_011541731.1	STKc_CDKL2_3	2..298	CDD:270836	98/307 (32%)