DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and cdk2

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001008136.1	Gene:	cdk2 / 493498	XenbaseID:	XB-GENE-1001990	Length:	297	Species:	Xenopus tropicalis

Alignment Length:	289	Identity:	191/289 - (66%)
Similarity:	233/289 - (80%)	Gaps:	3/289 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            ::|||:.|||||||||:|||||:..||:.||||||||:.|||||||||||||||||.|.|||:|:
Frog     1 MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKK-DVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            |.||:.:.|.||::||:||.||||.||... ...:..|:|||:.|:|..:.|||::|:|||||||
Frog    66 LLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKP 130

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSE 198
            ||||:::.|.||||||||||||.||:|.||||||||||||||||||.|||||.||||||||||:|
Frog   131 QNLLINSEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAE 195

  Fly   199 MIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQ--PITEHEAH 261
            ||.||:|||||||||||:||||||.||||.:|||||.:||:|:.||:|...:..:  |..:.:..
Frog   196 MITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWVRQDFSKVVPPLDDDGR 260

  Fly   262 ELIMSMLCYDPNLRISAKDALQHAYFRNV 290
            :|:..||.||.|.|||||.||.||:||:|
Frog   261 DLLAQMLQYDSNKRISAKAALTHAFFRDV 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	191/289 (66%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	187/281 (67%)
cdk2	NP_001008136.1	STKc_CDK2_3	3..286	CDD:270844	188/282 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	385	1.000	Domainoid score	I806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74409
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1962
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	1	1.000	-	-		oto102377
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090