Protein Alignment Cdk2 and cdk8

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_989246.1
• Gene: cdk8 / 394856
• XenbaseID: XB-GENE-962267
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 318
• Identity: 118/318 - (37%)
• Similarity: 172/318 - (54%)
• Gaps: 51/318 - (16%)

  Fly    13 KIGEGTYGIVYKA--RSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVI 75
            |:|.||||.||||  :.....:|.|||:|    |..|:..:|.|||:||:.||||||:.|..|.:
 Frog    26 KVGRGTYGHVYKAKRKDGRDDRDYALKQI----EGTGISMSACREIALLRELKHPNVISLQKVFL 86

  Fly    76 S--GNNLYMIFEYLNMDLKKLMD-------KKKDVFTPQ-LIKSYMHQILDAVGFCHTNRILHRD 130
            |  ...::::|::...||..::.       .||.|..|: ::||.::||||.:.:.|.|.:||||
 Frog    87 SHADRKVWLLFDFAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRD 151

  Fly   131 LKPQNLLV----DTAGKIKLADFGLARAFNVPMRAYTH---EVVTLWYRAPEILLGTKFYSTGVD 188
            |||.|:||    ...|::|:||.|.||.||.|::....   .|||.||||||:|||.:.|:..:|
 Frog   152 LKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID 216

  Fly   189 IWSLGCIFSEMIMRRSLFPGDSE---------IDQLYRIFRTLSTPDETNWPGVTQLPDFKT--- 241
            ||::||||:|::....:|....|         .|||.|||..:..|.:.:|..:.::|:..|
 Frog   217 IWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLIK 281

  Fly   242 KFPRWEGTN------------MPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYF 287
            .|.|...||            .|...|.|    |:..:|..||..|||::.|:|..||
 Frog   282 DFRRNTYTNCSLIKYMEKHKVKPDSKTFH----LLQKLLTMDPIKRISSEQAMQDPYF 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	116/316 (37%)
cdk8	NP_989246.1	Interaction with CCNC. /evidence=ECO:0000250	1..15
		Protein Kinases, catalytic domain	3..335	CDD:473864	116/316 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..464