Protein Alignment Cdk2 and Cdkl5

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001408453.1
• Gene: Cdkl5 / 382253
• MGIID: 1278336
• Length: 979
• Species: Mus musculus
• Alignment Length: 326
• Identity: 114/326 - (34%)
• Similarity: 174/326 - (53%)
• Gaps: 39/326 - (11%)

  Fly     4 ILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVV 68
            :::.|:....:|||.||:|.|.|...|.:.||:||.:...|.|.|..|.:||:.:|:.||..|:|
Mouse     9 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIV 73

  Fly    69 QLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            :|.:.......||::|||:..::.:|:::..:...|:.:|||::|::.|:.:||.|.|:|||:||
Mouse    74 ELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKP 138

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRA-YTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFS 197
            :|||:.....:||.|||.||..:....| ||..|.|.|||:||:|||.. |...||:||:|||..
Mouse   139 ENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILG 202

  Fly   198 EMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKF----PRWEG-----TNMPQ 253
            |:...:.||||:||||||:.|.:.|.           .||..:.|.    ||:.|     .|.||
Mouse   203 ELSDGQPLFPGESEIDQLFTIQKVLG-----------PLPSEQMKLFYSNPRFHGLRFPAVNHPQ 256

  Fly   254 P-------ITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQHVDHVALPVDPNAGSASRLT 311
            .       |......:|:.::|..||..|...:..|.|..|:..:.:|.          |.||.|
Mouse   257 SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDR----------SPSRST 311

  Fly   312 R 312
            :
Mouse   312 K 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	108/295 (37%)
Cdkl5	NP_001408453.1	STKc_CDKL5	11..297	CDD:270838	108/297 (36%)