Protein Alignment Cdk2 and CDKL4

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 108/302 - (35%)
• Similarity: 180/302 - (59%)
• Gaps: 27/302 - (8%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEG-VPSTAIREISLLKNLKHPNVV 68
            ::.:::..|.|||:||:|:|.|:.::||.||:||. :|.|.:. |...|:|||.:||.|||||:|
Human     1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKF-VESEDDPVVKKIALREIRMLKQLKHPNLV 64

  Fly    69 QLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            .|.:|......::::|||.:..|...:::..:.....:|||.:.|.|.|:.|||.:..:|||:||
Human    65 NLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKP 129

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSE 198
            :|:|:...|.||:.|||.|:.. :|..|||..|.|.||||||:|:|...|.:.||||::||:|:|
Human   130 ENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAE 193

  Fly   199 MIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPR---WEGTNMPQP-----I 255
            ::..:.|:||.|::||||.|.|||.          ..:|..::.|..   :.|.::|:|     :
Human   194 LLTGQPLWPGKSDVDQLYLIIRTLG----------KLIPRHQSIFKSNGFFHGISIPEPEDMETL 248

  Fly   256 TE--HEAHELIMSML--C--YDPNLRISAKDALQHAYFRNVQ 291
            .|  .:.|.:.::.:  |  .:|:.|::....|:.:||.:.|
Human   249 EEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQ 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	105/293 (36%)
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	105/295 (36%)
		[NKR]KIAxRE	45..51		1/5 (20%)