DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and Cdk18

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001093976.1	Gene:	Cdk18 / 289019	RGDID:	1309523	Length:	451	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	144/304 - (47%)
Similarity:	205/304 - (67%)	Gaps:	16/304 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            |:.:.:.:|:|||||..|:|.||..|...||||:||||.| ||.|.|||||:||||:|||.|:|.
  Rat   118 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVT 181

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.|::.:..:|.::||||:.|||:.:|...::.....:|.:|.|:|..:.:||..:|||||||||
  Rat   182 LHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHNVKIFMFQLLRGLAYCHRRKILHRDLKPQ 246

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||::..|::||||||||||.:||.:.|::||||||||.|::|||:..|||.:|:|.:|||..||
  Rat   247 NLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEM 311

  Fly   200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKT-KFPRWEGTNMPQPITEH----- 258
            ...:.||||.:..::|:.|||.|.||.|.:|||||.:.:|:. .|||:    :|||:..|
  Rat   312 ATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRY----LPQPLLSHAPRLD 372

  Fly   259 -EAHELIMSMLCYDPNLRISAKDALQHAYFRN----VQHVDHVA 297
             |...|:.|:|.|:...|:||:.||.|.||::    |..:|..|
  Rat   373 TEGINLLTSLLLYESKSRMSAEAALSHPYFQSLGERVHQLDDTA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	142/298 (48%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	138/285 (48%)
Cdk18	NP_001093976.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..61
Cdk18	NP_001093976.1	PKc_like	115..402	CDD:419665	139/288 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920