DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk2 and cdc2

DIOPT Version :9

Sequence 1:	NP_001163666.1	Gene:	Cdk2 / 42453	FlyBaseID:	FBgn0004107	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001342995.1	Gene:	cdc2 / 2539869	PomBaseID:	SPBC11B10.09	Length:	297	Species:	Schizosaccharomyces pombe

Alignment Length:	295	Identity:	171/295 - (57%)
Similarity:	228/295 - (77%)	Gaps:	10/295 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNL----KHP 65
            ::|:|:.|||||||||:|||||...:|:.||:||||||.|:|||||||||||||||.:    ...
pombe     1 MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDENNRS 65

  Fly    66 NVVQLFDVVISGNNLYMIFEYLNMDLKKLMDKKKDV----FTPQLIKSYMHQILDAVGFCHTNRI 126
            |.|:|.|::.:.:.||::||:|:|||||.||:..:.    ..|:|::.:.:|:::.|.|||:.||
pombe    66 NCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRI 130

  Fly   127 LHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWS 191
            :||||||||||:|..|.:|||||||||:|.||:|.||||:|||||||||:|||::.|||||||||
pombe   131 IHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWS 195

  Fly   192 LGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQ--P 254
            :||||:|||.|..|||||||||::::||:.|.||:|..|||||.|.|:|:.||||:..::.:  |
pombe   196 VGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPGVTLLQDYKSTFPRWKRMDLHKVVP 260

  Fly   255 ITEHEAHELIMSMLCYDPNLRISAKDALQHAYFRN 289
            ..|.:|.||:.:||.|||..|||||.|||..|.|:
pombe   261 NGEEDAIELLSAMLVYDPAHRISAKRALQQNYLRD 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	171/295 (58%)
Cdk2	NP_001163666.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	168/288 (58%)
cdc2	NP_001342995.1	STKc_CDK1_CdkB_like	4..293	CDD:270829	168/288 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74409
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
TreeFam	1	0.960	-	-
	9	8.800