Protein Alignment Cdk2 and CILK1

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001362326.1
• Gene: CILK1 / 22858
• HGNCID: 21219
• Length: 639
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 110/287 - (38%)
• Similarity: 172/287 - (59%)
• Gaps: 5/287 - (1%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            ::.:....::|:||||.|...||..:|:.:|:||::.:..: ......:||:..||.|.|.|||:
Human     1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYS-WEECMNLREVKSLKKLNHANVVK 64

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.:|:...::||.||||:..:|.:|:.::..:|....|::.|:|||..:.|.|.:...||||||:
Human    65 LKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPE 129

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||......:|:|||||||... ....||..|.|.||||||:||.:..||:.:|:|::|||.:|:
Human   130 NLLCMGPELVKIADFGLAREIR-SKPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEV 193

  Fly   200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPD-FKTKFPRWEGTNMPQ--PITEHEAH 261
            ...|.||||.||||.:::|.:.|.||.:|:||...||.. ...::|:....|:..  |....||.
Human   194 YTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAV 258

  Fly   262 ELIMSMLCYDPNLRISAKDALQHAYFR 288
            :|:..||.:||..|.:|..||::.||:
Human   259 QLLRDMLQWDPKKRPTASQALRYPYFQ 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	108/281 (38%)
CILK1	NP_001362326.1	STKc_MAK_like	4..284	CDD:270824	108/281 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..639